Evidence map›Paper›PMID 26155412›Full record

ArticleOncoimmunology2015

Cervical (pre)neoplastic microenvironment promotes the emergence of tolerogenic dendritic cells via RANKL secretion.

Stéphanie A Demoulin, Joan Somja, Anaëlle Duray, Samuel Guénin, Patrick Roncarati, Philippe O Delvenne, Michael F Herfs, Pascale M Hubert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
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  7. Immune Dysfunction in Medication-Related Osteonecrosis of the Jaw.International journal of molecular sciences · 2023
    Review
  8. Article
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  11. Article
  12. Review
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  15. Article
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  17. Article
  18. Review
  19. Article
  20. The RANK-RANKL axis: an opportunity for drug repurposing in cancer?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Stéphanie A DemoulinLaboratory of Experimental Pathology; GIGA-Cancer; University of Liège ; Liège, Belgium.
Joan SomjaDepartment of Pathology; University Hospital of Liège ; Liège, Belgium.
Anaëlle DurayLaboratory of Experimental Pathology; GIGA-Cancer; University of Liège ; Liège, Belgium.
Samuel GuéninLaboratory of Experimental Pathology; GIGA-Cancer; University of Liège ; Liège, Belgium.
Patrick RoncaratiLaboratory of Experimental Pathology; GIGA-Cancer; University of Liège ; Liège, Belgium.
Philippe O DelvenneDepartment of Pathology; University Hospital of Liège ; Liège, Belgium.
Michael F HerfsLaboratory of Experimental Pathology; GIGA-Cancer; University of Liège ; Liège, Belgium.
Pascale M HubertLaboratory of Experimental Pathology; GIGA-Cancer; University of Liège ; Liège, Belgium.
University of Liège · BECentre Hospitalier Universitaire de Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The progression of genital human papillomavirus (HPV) infections into preneoplastic lesions suggests that infected/malignant cells are not adequately recognized by the immune system. In this study, we demonstrated that cervical/vulvar cancer cells secrete factor(s) that affect both the maturation and function of dendritic cells (DC) leading to a tolerogenic profile. Indeed, DC cocultured with cancer cell lines display both a partially mature phenotype after lipopolysaccharide (LPS) maturation and an altered secretory profile (IL-10

Indexed as

APC, antigen presenting cells; DC, dendritic cellscervical cancersdendritic cellsGILZ, glucocorticoid-induced leucine zipper; HPV, human papillomavirusHSIL, high grade intraepithelial lesionsIHC, immunohistochemistryILT3, Immunoglobulin-like transcript 3KN, normal keratinocytesLC, Langerhans cells; LPS, lipopolysaccharideLSIL, low grade intraepithelial lesionMFI, mean fluorescence intensityOPG, osteoprotegerinPBMC, peripheral blood mononuclear cells; pDC, plasmacytoid dendritic cellsRANKLRANKL, Receptor activator of nuclear factor kappa-B ligandSCC, squamous cell carcinomaSIL, squamous intraepithelial neoplasiatolerogenicityTreg cellsTreg cells, regulatory T cellsVIN, vulvar intraepithelial neoplasia

Identifiers

PMID26155412
PMCPMC4485731
OpenAlexW2101448571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.