Evidence map›Paper›PMID 26155392›Full record

ArticleOncoimmunology2015

The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression.

Limo Chen, John V Heymach, F Xiao-Feng Qin, Don L Gibbons

Abstract read
In one paragraph

Article in Oncoimmunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Advanced Melanoma: Resistance Mechanisms to Current Therapies.Hematology/oncology clinics of North America · 2021
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. The Cellular Origin and Evolution of Breast Cancer.Cold Spring Harbor perspectives in medicine · 2017
    Review
  18. Article
  19. Article
  20. Immune Regulation and Antitumor Effect of TIM-1.Journal of immunology research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Limo ChenDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
John V HeymachDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.
F Xiao-Feng QinDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Center of Systems Medicine, Institute of Basic Medical Sciences , Suzhou, China ; Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing, China.
Don L GibbonsDepartment of Thoracic/Head and Neck Medical Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA ; Department of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center ; Houston, TX USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-mesenchymal transition and immunosuppression are crucial for cancer metastasis and treatment resistance. The mechanism by which these distinct processes are co-opted remains incompletely understood. Our recent work has exposed the "dirty affairs" of the 2 at the tumor site, thus calling for a combined therapy to break such a dangerous liaison.

Indexed as

epithelial–mesenchymal transitionimmunosuppressionmiRNAtherapy resistancetumor microenvironment

Identifiers

PMID26155392
PMCPMC4485725

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.