Evidence map›Paper›PMID 26155169›Full record

ArticleCentral-European journal of immunology2014

Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis.

Asli Dogruk Unal, Ozlem Tarcin, Hulya Parildar, Ozlem Cigerli, Hacer Eroglu, Nilgun Guvener Demirag

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central-European journal of immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  10. Autoimmune Thyroiditis and Vitamin D.International journal of molecular sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Asli Dogruk UnalDepartment of Endocrinology and Metabolism, Baskent University Istanbul Hospital, Istanbul, Turkey.
Ozlem TarcinDepartment of Endocrinology and Metabolism, Baskent University Istanbul Hospital, Istanbul, Turkey.
Hulya ParildarDepartment of Family Medicine, Baskent University Istanbul Hospital, Istanbul, Turkey.
Ozlem CigerliDepartment of Family Medicine, Baskent University Istanbul Hospital, Istanbul, Turkey.
Hacer ErogluDepartment of Biochemistry, Baskent University Istanbul Hospital, Istanbul, Turkey.
Nilgun Guvener DemiragDepartment of Endocrinology and Metabolism, Baskent University Istanbul Hospital, Istanbul, Turkey.
Başkent University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIt has been known that vitamin D has some immunomodulatory effects and in autoimmune thyroid diseases, vitamin D deficiency was more prevalent. In this study, our aim was to investigate the relationship between thyroid autoantibodies and vitamin D. MATERIAL AND

methodsGroup 1 and 2 consisted of 254 and 27 newly diagnosed Hashimoto's thyroiditis (HT) and Graves' disease (GD) cases, respectively; age-matched 124 healthy subjects were enrolled as controls (group 3). All subjects (n = 405) were evaluated for 25OHD and thyroid autoantibody [anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin (anti-tg)] levels.

resultsGroup 2 and group 1 patients had lower 25OHD levels than group 3 subjects 14.9 ±8.6 ng/ml, 19.4 ±10.1 ng/ml and 22.5 ±15.4 ng/ml, respectively (p < 0.001). Serum 25OHD levels inversely correlated with anti-tg (r = -0.136, p = 0.025), anti-TPO (r = -0.176, p = 0.003) and parathormone (PTH) (r = -0.240, p < 0.001). Group 2 patients had higher anti-tg and anti-TPO levels than group 1 and 3 (p < 0.001).

conclusionsIn this study, we found that patients with autoimmune thyroid disease (AITD) present with lower vitamin D levels and GD patients have higher prevalence. Since we found an inverse correlation between vitamin D levels and thyroid antibody levels, we may suggest that vitamin D deficiency is one of the potential factors in pathogenesis of autoimmune thyroid disorders.

Indexed as

autoimmunitythyroidvitamin D

Identifiers

PMID26155169
PMCPMC4439962
OpenAlexW2417639902

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.