Evidence map›Paper›PMID 26155134›Full record

ArticleCentral-European journal of immunology2014

Dendritic cell-glioma fusion activates T lymphocytes by elevating cytotoxic efficiency as an antitumor vaccine.

Fuming Tian, Changwu Dou, Songtao Qi, Bo Chen, Liqun Zhao, Xiaojuan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central-European journal of immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Fuming TianDepartment of Neurosurgery, Nanfang Hospital, Southern Medial University, Guangzhou, PR China ; Department of Neurosurgery, First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia.
Changwu DouDepartment of Neurosurgery, First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia.
Songtao QiDepartment of Neurosurgery, Nanfang Hospital, Southern Medial University, Guangzhou, PR China.
Bo ChenDepartment of Neurosurgery, First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia.
Liqun ZhaoDepartment of Neurosurgery, First Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia.
Xiaojuan WangGuangdong Foshan Medical University, Foshan, Guangdong, PR China.
Mongolian National University · MNNanfang Hospital · CNFoshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHybrid cells produced by fusions of tumor and dendritic cells (DC) have demonstrated remarkable efficacy for priming the anti-tumor immune response. In the current study, we examined the antitumor activity of cytotoxic T lymphocytes (CTLs) primed in response to a tumor vaccine comprising a glioma-DC fusion as part of a therapeutic against glioma. MATERIAL AND

methodsPrimary cultured glioma cells were fused with peripheral blood DC under conditions of polyethylene glycol (PEG) incubation. Glioma cell suspensions were designated as three groups to include (1) CTL-effective cell group activated by fused cells; (2) CTL-effective cell group stimulated by co-cultured glioma cells and DC cells; and (3) lymphocyte-only group as a control, which was not stimulated by the DC. Cytotoxicity of CTLs on glioma cells was accessed by MTT assay in vitro.

resultsGlioma cells with peripheral blood DC were cultured and fused. The killing effect of CTLs pre-activated by fused cells was significantly higher than that of the co-culture CTL group with unsensitized lymphocytes (p < 0.01). The killing activity, as measured by an enhanced efficiency ratio, was increased significantly in the co-cultures of fused cells with CTL groups (p < 0.01).

conclusionsThe glioma-dendritic cell fusion vaccine possessed a more effective anticancer activity by stimulating the effector activity of CTLs.

Indexed as

cytotoxic T lymphocytedendritic celldendritic cell/glioma fusionglioma cell

Identifiers

PMID26155134
PMCPMC4439993
OpenAlexW2181503288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.