ArticleCentral-European journal of immunology2014
The effect of Zingiber officinale R. rhizomes (ginger) on plasma pro-inflammatory cytokine levels in well-trained male endurance runners.
Article in Central-European journal of immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Antioxidant and anti-inflammatory effects of ginger supplementation in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomised controlled trials.Inflammopharmacology · 2025Pooled it
- Ginger for Healthy Ageing: A Systematic Review on Current Evidence of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties.Oxidative medicine and cellular longevity · 2022Pooled it
- Effects of Ginger Supplementation on Markers of Inflammation and Functional Capacity in Individuals with Mild to Moderate Joint Pain.Nutrients · 2025Trial
- Analysis of Effectiveness of a Supplement CombiningInternational journal of environmental research and public health · 2021Trial
- A Review of the Properties of Clinically Evaluated Plant-Derived Agents in the Treatment of Respiratory Infections.Nutrients · 2026Review
- The Influence of Ginger Supplementation on Cycling Performance.Sports (Basel, Switzerland) · 2026Article
- Steamed ginger extract ameliorates the symptoms of osteoarthritis in monosodium iodoacetate-induced osteoarthritis rats.Nutrition research and practice · 2025Article
- Steamed Ginger Extract (GGE03) Attenuates Obesity and Improves Metabolic Parameters in Association with AMPK Activation and Lipid Metabolism Regulation in High-Fat Diet-Induced Obese Mice.International journal of molecular sciences · 2025Article
- Advancements in neuroblastoma treatment: FDA-approved drugs and role of phytochemicals.Molecular biology reports · 2025Review
- A recent update on the connection between dietary phytochemicals and skin cancer: emerging understanding of the molecular mechanism.Annals of medicine and surgery (2012) · 2024Review
- Intra-peritoneal lavage ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024Article
- Nutraceuticals and Pain Disorders of the Gut-Brain Interaction in Infants and Children: A Narrative Review and Practical Insights.Nutrients · 2024Review
- Ginger supplement significantly reduced length of hospital stay in individuals with COVID-19.Nutrition & metabolism · 2022Article
- Nutritional Compounds to Improve Post-Exercise Recovery.Nutrients · 2022Review
- Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.Nutrients · 2022Review
- Safety and Efficacy of Medicinal Plants Used to Manufacture Herbal Products with Regulatory Approval in Uganda: A Cross-Sectional Study.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Ginger extract suppresses the activations of NF-κB and Wnt pathways and protects inflammatory arthritis.European journal of rheumatology · 2021Article
- The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial.Food science and biotechnology · 2020Article
- Effect of a Blend ofFrontiers in physiology · 2020Article
- Bioactive Compounds and Bioactivities of Ginger (Foods (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effect of ginger on the concentrations of plasma interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in welltrained male endurance runners. To this end, twenty-eight high-level endurance runners were randomly assigned to two groups (control and experimental). They performed the same weekly training volume for 12 weeks. The Bruce treadmill test was used three days before the start of the 12-week training period and after weeks 6 and 12 to evaluate the physiological effects of training and ginger administration. After completing the first 6-week period of exercise training protocol, two groups received 500 mg capsules of ginger powder and placebo, respectively, three times a day for the second 6-week period. Blood samples were collected before (resting blood sample) and after the Bruce treadmill test. IL-1β, IL-6 and TNF-α were assayed using standard commercial ELISA kits. Two-way repeated measures analysis of variance (ANOVA) was used to determine significant differences between control and experimental plasma IL-6, IL-1β and TNF-α concentration means of pre- and post-test periods. The IL-1β, IL-6 and TNF-α concentrations at the end of week 12/weeks 6 and 12 between two training groups were significantly different (p = 0.01, p = 0.01, and p = 0.01). In the experimental group alone, there were also significant differences in the mean IL-1β, IL-6 and TNF-α concentrations at the end of weeks 6 and 12 (p = 0.01, p = 0.01, and p = 0.01). Our findings indicated that post-exercise plasma elevations of several pro-inflammatory cytokines can be attenuated by a six-week ginger administration period.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.