Evidence map›Paper›PMID 26155043›Full record

ReviewJournal of clinical and experimental hepatology2015

The Riddle of Nonalcoholic Fatty Liver Disease: Progression From Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis.

Mithun Sharma, Shasikala Mitnala, Ravi K Vishnubhotla, Rathin Mukherjee, Duvvur N Reddy, Padaki N Rao

Abstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Antioxidants (Basel, Switzerland) · 2024
    Article
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  9. Review
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  14. Review
  15. Article
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  19. Article
  20. Article

6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mithun SharmaDepartment of Hepatology and Nutrition, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
Shasikala MitnalaResearch Labs, Institute of Basic Sciences and Translational Research, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
Ravi K VishnubhotlaDepartment of Genetics, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
Rathin MukherjeeDepartment of Molecular Biology, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
Duvvur N ReddyDepartment of Gastroenterology, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.
Padaki N RaoDepartment of Hepatology and Nutrition, Asian Healthcare Foundation, Asian Institute of Gastroenterology, Hyderabad, Telangana, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonalcoholic fatty liver (NAFL) is an emerging global epidemic which progresses to nonalcoholic steatohepatitis (NASH) and cirrhosis in a subset of subjects. Various reviews have focused on the etiology, epidemiology, pathogenesis and treatment of NAFLD. This review highlights specifically the triggers implicated in disease progression from NAFL to NASH. The integrating role of genes, dietary factors, innate immunity, cytokines and gut microbiome have been discussed.

Indexed as

adiponectinAGE, Advanced glycation end productsALT, Alanine aminotransferaseAMPK, AMP-activated protein KinaseAPPL1 and 2, Adaptor protein 1 and 2ATP, Adenosine tri-phosphataseBMI, Basal Metabolic IndexCD, Cluster of differentiationCOL13A1, Collagen, type XIII, alpha 1cytokinesDAMP, Damage assocauted molecular pattern moleculesEFCAB4B, EF-hand calcium binding domain 4BFA, Fatty acidFDFT1, Farnesyl-diphosphate farnesyltransferase 1FFA, Free fatty acidGCKR, Glucokinase regulatory proteinGLUT 5, Glucose transporter type 5gut microbiotaGWAS, Genome wide association studiesHDL, High density lipoproteinHh, HedgehogHMGB1, High-mobility group protein B1HOMA-IR, Homoestatic model assessment-insulin resistanceHSC, Hepatic Stellate CellsIL6, Interleukin 6IR, Insulin ResistanceKC, Kupffer CellslipotoxicityLPS, LipopolysacharridesLYPLAL1, Lypophospholipase like 1MCP, Monocyte chemotactic proteinNAD, Nicotinamide adenine dinucleotideNAFLD, Nonalcoholic fatty liver diseaseNAFL, Nonalcoholic fatty liverNASH, Nonalcoholic steatohepatitisNCAN, Neurocan geneNF-KB, Nuclear Factor Kappa BNKL, Natural Killer T cellsNK, Natural KillerNLR, NOD like receptorNNMT, Nicotinamide N-methyltransferase geneOXLAM, Oxidized linolenic acid metabolitePAMP, Pathogen-associated Molecular patternPARVB, Beta Parvin GenePDGF, Platelet-derived growth factorPNPLA3PNPLA3, Patatin-like phospholipase domain-containing protein 3PPAR-α, Peroxisome proliferator activated receptor alphaPPP1R3B, Protein phosphatase 1 R3BPUFA, Poly unsaturated fatty acidPZP, Pregnancy-zone proteinROS, Reactive oxygen speciesSAMM, Sorting and assembly machinery componentSCAP, SREBP cleavage-activating proteinSFA, Saturated fatty acidSNP, Single nucleotide polymorphismSOCS3, Suppressor of cytokine signaling 3SOD2, Superoxide dismutase 2 geneSREBP-1C, Sterol regulatory Element—Binding Protein 1-C geneTLR, Toll like receptorTNF α, Tumor necrosis factor AlphaUCP3, Uncoupling protein 3 gene

Identifiers

PMID26155043
PMCPMC4491606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.