Observational studyCritical care medicine2015
Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients.
Observational study in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 158 citations in OpenAlex.
- Beta-blocker treatment in the critically ill: a systematic review and meta-analysis.Annals of medicine · 2022Pooled it
- Article
- A prospective, multi-site, observational study assessing the treatment thresholds of new onset atrial fibrillation in the critically ill.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- The association between albumin/neutrophil-to-lymphocyte ratio score and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from Medical Information Mart for Intensive Care IV (MIMIC-IV) database.Journal of thoracic disease · 2026Article
- Clinical Profiles of Hospitalized Middle Eastern Patients With Nonvalvular Atrial Fibrillation: Analysis From the JoFib Study.International journal of vascular medicine · 2026Article
- Interpretable machine learning to predict NOAF in ICU patients with CKD: validation in US and Chinese cohorts.Frontiers in medicine · 2026Article
- Seasonal variations in hospital admissions and case-fatality of ischemic stroke: a nationwide analysis of >4.2 million cases in Germany.Frontiers in epidemiology · 2026Article
- Guidelines for the management of atrial fibrillation in adult patients admitted to an intensive care unit.Annals of intensive care · 2026Article
- To explore the relationship between multiple glycemic markers and all-cause mortality in patients with severe atrial fibrillation based on multiple databases.Scientific reports · 2025Article
- Association between heart rate fluctuation and mortality in intensive care patients with atrial fibrillation.Scientific reports · 2025Article
- Usefulness of Blood-Urea-Nitrogen to Serum Albumin Ratio for In-hospital Mortality Predictions in Atrial Fibrillation Patients Admitted to the Intensive Care Unit: A Retrospective Analysis From MIMIC-IV Database.Reviews in cardiovascular medicine · 2025Article
- Joint association of the triglyceride-glucose index and stress hyperglycemia ratio with incidence and mortality risks of new-onset atrial fibrillation during sepsis: a retrospective cohort study.Cardiovascular diabetology · 2025Article
- Development of an Extended Cardiovascular SOFA Score Component Reflecting Cardiac Dysfunction with Improved Survival Prediction in Sepsis: An Exploratory Analysis in the Sepsis and Elevated Troponin (SET) Study.Journal of intensive care medicine · 2025Article
- Beyond the Beat: A Multifaceted Review of Atrial Fibrillation in Sepsis: Risk Factors, Management Strategies, and Economic Impact.Cardiology research · 2025Review
- Comparison of the efficacy and safety of Landiolol and Esmolol in critically ill patients: a propensity score-matched study.Annals of intensive care · 2025Article
- Article
- Targeted Heart Rate Control in Sepsis: A Promising Path or a Double-edged Sword?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Prevalence, Risk Factors, and Mortality of New-Onset Atrial Fibrillation in Mechanically Ventilated Critically Ill Patients.Journal of clinical medicine · 2024Article
- Edoxaban pharmacokinetics during in vitro continuous renal replacement therapy.BMC nephrology · 2024Article
- Evaluation of Amiodarone Administration in Patients with New-Onset Atrial Fibrillation in Septic Shock.Medicina (Kaunas, Lithuania) · 2024Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesAtrial fibrillation has been associated with increased mortality in critically ill patients. We sought to determine whether atrial fibrillation in the ICU is an independent risk factor for death. A secondary objective was to determine if patients with new-onset atrial fibrillation have different risk factors or outcomes compared with patients with a previous history of atrial fibrillation.
designProspective observational cohort study.
settingMedical and general surgical ICUs in a tertiary academic medical center. PATIENTS: One thousand seven hundred seventy critically ill patients requiring at least 2 days in the ICU.
interventionsNone. MEASUREMENTS AND MAIN
resultsDemographics, medical history, development of atrial fibrillation, fluid balance, echocardiographic findings, medication administration, and hospital mortality were collected during the first 4 days of ICU admission. Atrial fibrillation occurred in 236 patients (13%) (Any AF). Of these, 123 patients (7%) had no prior atrial fibrillation (New-onset AF) while the remaining 113 (6%) had recurrent atrial fibrillation (Recurrent AF). Any AF was associated with male gender, Caucasian race, increased age, cardiac disease, organ failures, and disease severity. Patients with Any AF had increased mortality compared with those without atrial fibrillation (31% vs 17%; p < 0.001), and Any AF was independently associated with death (odds ratio, 1.62; 95% CI, 1.14-2.29; p = 0.007) in multivariable analysis controlling for severity of illness and other confounders. The association of atrial fibrillation with death was magnified in patients without sepsis (odds ratio, 2.92; 95% CI, 1.52-5.60; p = 0.001). Treatment for atrial fibrillation had no effect on hospital mortality. New-onset AF and Recurrent AF were each associated with increased mortality. New-onset AF, but not Recurrent AF, was associated with increased diastolic dysfunction and vasopressor use and a greater cumulative positive fluid balance.
conclusionsAtrial fibrillation in critical illness, whether new-onset or recurrent, is independently associated with increased hospital mortality, especially in patients without sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.