ArticleScientific reports2015
Metagenomic sequencing reveals altered metabolic pathways in the oral microbiota of sailors during a long sea voyage.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Travel microbiota: a novel frontier in travel medicine exploring microbial shifts across transportation modes.Tropical diseases, travel medicine and vaccines · 2026Review
- Role of regulatory immune cells in pathogenesis and therapy of periodontitis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Carotenoids in Health as Studied by Omics-Related Endpoints.Advances in nutrition (Bethesda, Md.) · 2023Review
- Effects of Unconventional Work and Shift Work on the Human Gut Microbiota and the Potential of Probiotics to Restore Dysbiosis.Nutrients · 2023Review
- TheFrontiers in microbiology · 2023Review
- Alterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage.Microbiology spectrum · 2022Article
- Interactions between Human Gut Microbiome Dynamics and Sub-Optimal Health Symptoms during Seafaring Expeditions.Microbiology spectrum · 2022Article
- The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives.FEMS microbiology reviews · 2021Review
- Probiotics maintain the intestinal microbiome homeostasis of the sailors during a long sea voyage.Gut microbes · 2020Article
- Oral Microbiome Analysis in Prospective Genome Cohort Studies of the Tohoku Medical Megabank Project.Frontiers in cellular and infection microbiology · 2020Article
- Metagenomic deep sequencing reveals association of microbiome signature with functional biases in bovine mastitis.Scientific reports · 2019Article
- Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project.JMA journal · 2019Article
- Diversity and functional analysis of salivary microflora of Indian Antarctic expeditionaries.Journal of oral microbiology · 2019Article
- Metatranscriptome of the Oral Microbiome in Health and Disease.Journal of dental research · 2018Review
- Current understanding of the human microbiome.Nature medicine · 2018Review
- [The microbiome and autoimmunity].Der Internist · 2017Review
- GRASPx: efficient homolog-search of short peptide metagenome database through simultaneous alignment and assembly.BMC bioinformatics · 2016Article
- A Bayesian inference method for the analysis of transcriptional regulatory networks in metagenomic data.Algorithms for molecular biology : AMB · 2016Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seafaring is a difficult occupation, and sailors face higher health risks than individuals on land. Commensal microbiota participates in the host immune system and metabolism, reflecting the host's health condition. However, the interaction mechanisms between the microbiota and the host's health condition remain unclear. This study reports the influence of long sea voyages on human health by utilising a metagenomic analysis of variation in the microbiota of the buccal mucosa. Paired samples collected before and after a sea-voyage were analysed. After more than 120 days of ocean sailing, the oral microbial diversity of sailors was reduced by approximately 5 fold, and the levels of several pathogens (e.g., Streptococcus pneumonia) increased. Moreover, 69.46% of the identified microbial sequences were unclassified microbiota. Notably, several metabolic pathways were dramatically decreased, including folate biosynthesis, carbohydrate, lipid and amino acid pathways. Clinical examination of the hosts confirmed the identified metabolic changes, as demonstrated by decreased serum levels of haemoglobin and folic acid, a decreased neutrophil-to-lymphocyte ratio, and increased levels of triglycerides, cholesterol and homocysteine, which are consistent with the observed microbial variation. Our study suggests that oral mucosal bacteria may reflect host health conditions and could provide approaches for improving the health of sailors.
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