ArticlePloS one2015
Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The epidemiology of seasonal influenza after the 2009 influenza pandemic in Africa: a systematic review.African health sciences · 2020Pooled it
- The National Burden of Influenza-Associated Respiratory Illness Across Levels of Severity in Egypt, 2016-2019.Influenza and other respiratory viruses · 2024Article
- Article
- Article
- Article
- The burden of RSV-associated illness in children aged < 5 years, South Africa, 2011 to 2016.BMC medicine · 2023Article
- Estimating the cost-effectiveness of maternal vaccination and monoclonal antibodies for respiratory syncytial virus in Kenya and South Africa.BMC medicine · 2023Article
- Approaches to use the WHO respiratory syncytial virus surveillance platform to estimate disease burden.Influenza and other respiratory viruses · 2020Article
- Age-dependent effects in the transmission and control of COVID-19 epidemics.Nature medicine · 2020Article
- Article
- Quantifying How Different Clinical Presentations, Levels of Severity, and Healthcare Attendance Shape the Burden of Influenza-associated Illness: A Modeling Study From South Africa.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Burden and epidemiology of influenza- and respiratory syncytial virus-associated severe acute respiratory illness hospitalization in Madagascar, 2011-2016.Influenza and other respiratory viruses · 2019Article
- The national and provincial burden of medically attended influenza-associated influenza-like illness and severe acute respiratory illness in the Democratic Republic of Congo, 2013-2015.Influenza and other respiratory viruses · 2018Article
- Impact of Human Immunodeficiency Virus on the Burden and Severity of Influenza Illness in Malawian Adults: A Prospective Cohort and Parallel Case-Control Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Uptake and cost of influenza vaccines in a private health insured South African population.Southern African journal of infectious diseases · 2018Article
- The national burden of influenza-associated severe acute respiratory illness hospitalization in Rwanda, 2012-2014.Influenza and other respiratory viruses · 2018Article
- The national burden of influenza-associated severe acute respiratory illness hospitalization in Zambia, 2011-2014.Influenza and other respiratory viruses · 2018Article
- National burden of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness in Kenya, 2012-2014.Influenza and other respiratory viruses · 2018Article
- Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011-June 2015.International journal of environmental research and public health · 2017Article
- Risk Factors for Influenza-Associated Severe Acute Respiratory Illness Hospitalization in South Africa, 2012-2015.Open forum infectious diseases · 2017Article
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local disease burden data are necessary to set national influenza vaccination policy. In 2010 the population of South Africa was 50 million and the HIV prevalence was 11%. We used a previously developed methodology to determine severe influenza burden in South Africa. Hospitalized severe acute respiratory illness (SARI) incidence was calculated, stratified by HIV status, for four age groups using data from population-based surveillance in one site situated in Gauteng Province for 2009-2011. These rates were adjusted for each of the remaining 8 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. We estimated non-hospitalized influenza-associated SARI from healthcare utilization surveys at two sites and used the percent of SARI cases positive for influenza from sentinel surveillance to derive the influenza-associated SARI rate. We applied rates of hospitalized and non-hospitalized influenza-associated SARI to census data to calculate the national number of cases. The percent of SARI cases that tested positive for influenza ranged from 7-17% depending on age group, year, province and HIV status. In 2010, there were an estimated 21,555 total severe influenza cases in HIV-uninfected individuals and 13,876 in HIV-infected individuals. In 2011, there were an estimated 29,892 total severe influenza cases in HIV-uninfected individuals and 17,289 in HIV-infected individuals. The incidence of influenza-associated SARI was highest in children <5 years and was higher in HIV-infected than HIV-uninfected persons in all age groups. Influenza virus was associated with a substantial amount of severe disease, especially in young children and HIV-infected populations in South Africa.
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