ArticlePloS one2015
The Relationship between Runs of Homozygosity and Inbreeding in Jersey Cattle under Selection.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Runs of Homozygosity Predict Inbreeding Depression Across Taxa: A Systematic Review and Meta-Analysis.Molecular ecology · 2026Pooled it
- A genome-structure adaptive framework for ROH-based inbreeding estimation in Penaeus vannamei.Scientific reports · 2026Article
- Genome-Wide Association Studies of Growth Trait Heterosis in Crossbred Meat Rabbits.Animals : an open access journal from MDPI · 2024Article
- Homozygosity mapping in the Kazakh national dog breed Tazy.Scientific reports · 2023Article
- Genomic consequences of a century of inbreeding and isolation in the Danish wild boar population.Evolutionary applications · 2022Article
- Sequencing Reveals Population Structure and Selection Signatures for Reproductive Traits in Yunnan Semi-Fine Wool Sheep (Frontiers in genetics · 2022Article
- Integrative QTL mapping and selection signatures in Groningen White Headed cattle inferred from whole-genome sequences.PloS one · 2022Article
- Runs of homocigosity and its association with productive traits in Mexican Holstein cattle.PloS one · 2022Article
- Identification of Homozygous Regions With Adverse Effects on the Five Economic Traits of Duroc Pigs.Frontiers in veterinary science · 2022Article
- Correlation of Genomic and Pedigree Inbreeding Coefficients in Small Cattle Populations.Animals : an open access journal from MDPI · 2021Article
- Genome-wide selection signatures detection in Shanghai Holstein cattle population identified genes related to adaption, health and reproduction traits.BMC genomics · 2021Review
- Estimates of genomic inbreeding and identification of candidate regions that differ between Chinese indigenous sheep breeds.Journal of animal science and biotechnology · 2021Article
- Ethiopian indigenous goats offer insights into past and recent demographic dynamics and local adaptation in sub-Saharan African goats.Evolutionary applications · 2021Article
- Runs of homozygosity analysis of South African sheep breeds from various production systems investigated using OvineSNP50k data.BMC genomics · 2021Article
- Genetic diversity and population history of eight Italian beef cattle breeds using measures of autozygosity.PloS one · 2021Article
- Genetic composition of queen conch (Lobatus gigas) population on Pedro Bank, Jamaica and its use in fisheries management.PloS one · 2021Article
- Runs of homozygosity and analysis of inbreeding depression.Journal of animal science · 2020Article
- Genome-Wide Assessment of Runs of Homozygosity in Chinese Wagyu Beef Cattle.Animals : an open access journal from MDPI · 2020Article
- Genetic variants in the TORC2 gene promoter and their association with body measurement and carcass quality traits in Qinchuan cattle.PloS one · 2020Article
- Genome-Wide Runs of Homozygosity Revealed Selection Signatures inFrontiers in genetics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inbreeding is often an inevitable outcome of strong directional artificial selection but on average it reduces population fitness with increased frequency of recessive deleterious alleles. Runs of homozygosity (ROH) representing genomic autozygosity that occur from mating between selected and genomically related individuals may be able to reveal the regions affecting fitness. To examine the influence of genomic autozygosity on fitness, we used a genome-wide association test to evaluate potential negative correlations between ROH and daughter pregnancy rate (DPR) or somatic cell score (SCS) in US Jersey cattle. In addition, relationships between changes of local ROH and inbreeding coefficients (F) were assessed to locate genomic regions with increased inbreeding. Despite finding some decreases in fertility associated with incremental increases in F, most emerging local ROH were not significantly associated with DPR or SCS. Furthermore, the analyses of ROH could be approximated with the most frequent haplotype(s), including the associations of ROH and F or traits. The analysis of the most frequent haplotype revealed that associations of ROH and fertility could be accounted for by the additive genetic effect on the trait. Thus, we suggest that a change of autozygosity is more likely to demonstrate footprints of selected haplotypes for production rather than highlight the possible increased local autozygosity of a recessive detrimental allele resulting from the mating between closely related animals in Jersey cattle.
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