ArticlePloS one2015
Impact of Noncommunicable Disease Multimorbidity on Healthcare Utilisation and Out-Of-Pocket Expenditures in Middle-Income Countries: Cross Sectional Analysis.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 13 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
155 citing papers in PubMed, 13 syntheses or guidelines pooled it, 285 citations in OpenAlex.
- Magnitude of catastrophic health expenditure and its determinants among cancer patients in low and middle-income countries: a systematic review and meta-analysis.BMC health services research · 2025Pooled it
- Consequences of Population Ageing on Health Systems: A Conceptual Framework for Policy and Practice.Ethiopian journal of health sciences · 2025Pooled it
- Core outcome sets for trials of interventions to prevent and to treat multimorbidity in adults in low and middle-income countries: the COSMOS study.BMJ global health · 2024Pooled it
- Understanding variation in catastrophic health expenditure from socio-ecological aspect: a systematic review.BMC public health · 2024Pooled it
- Determinants of multimorbidity in low- and middle-income countries: A systematic review of longitudinal studies and discovery of evidence gaps.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Prevalence of Multimorbidity in the Middle East: A Systematic Review of Observational Studies.International journal of environmental research and public health · 2022Pooled it
- Community prevalence and dyad disease pattern of multimorbidity in China and India: a systematic review.BMJ global health · 2022Pooled it
- Association between multimorbidity and hospitalization in older adults: systematic review and meta-analysis.Age and ageing · 2022Pooled it
- Multimorbidity of non-communicable diseases in low-income and middle-income countries: a systematic review and meta-analysis.BMJ open · 2022Pooled it
- Medical injection and access to sterile injection equipment in low- and middle-income countries: a meta-analysis of Demographic and Health Surveys (2010-2017).International health · 2020Pooled it
- Leaving no one behind? Social inclusion of health insurance in low- and middle-income countries: a systematic review.International journal for equity in health · 2019Pooled it
- Fish consumption and risk of all-cause and cardiovascular mortality: a dose-response meta-analysis of prospective observational studies.Public health nutrition · 2018Pooled it
- The economic impact of non-communicable diseases among households in South Asia and their coping strategy: A systematic review.PloS one · 2018Pooled it
- Understanding the Impact of Different Doses of ReducoseNutrients · 2024Trial
- Pattern and severity of multimorbidity among patients attending primary care settings in Odisha, India.PloS one · 2017Trial
- Forecasting the Multidimensional Burdens of Hospital Admissions in LRTIs and COPD: Projections of Healthcare Expenditures, Resource Utilization, and Socioeconomic and Environmental Outcomes for Switzerland.Infectious diseases and therapy · 2026Article
- Pharmaceutical import landscape in Ethiopia: a cross-sectional study of importers' perspectives on business and regulatory challenges.Tropical medicine and health · 2026Article
- Clustering of multimorbidity in stroke and transient ischaemic attack survivors: a population-based study.BMC medicine · 2026Article
- Article
- Epidemiology of multimorbidity among indigenous adults: Insights from a large-scale population survey of 53 different indigenous groups in East India.Global epidemiology · 2025Article
95 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundThe burden of non-communicable disease (NCDs) has grown rapidly in low- and middle-income countries (LMICs), where populations are ageing, with rising prevalence of multimorbidity (more than two co-existing chronic conditions) that will significantly increase pressure on already stretched health systems. We assess the impact of NCD multimorbidity on healthcare utilisation and out-of-pocket expenditures in six middle-income countries: China, Ghana, India, Mexico, Russia and South Africa.
methodsSecondary analyses of cross-sectional data from adult participants (>18 years) in the WHO Study on Global Ageing and Adult Health (SAGE) 2007-2010. We used multiple logistic regression to determine socio-demographic correlates of multimorbidity. Association between the number of NCDs and healthcare utilisation as well as out-of-pocket spending was assessed using logistic, negative binominal and log-linear models.
resultsThe prevalence of multimorbidity in the adult population varied from 3.9% in Ghana to 33.6% in Russia. Number of visits to doctors in primary and secondary care rose substantially for persons with increasing numbers of co-existing NCDs. Multimorbidity was associated with more outpatient visits in China (coefficient for number of NCD = 0.56, 95% CI = 0.46, 0.66), a higher likelihood of being hospitalised in India (AOR = 1.59, 95% CI = 1.45, 1.75), higher out-of-pocket expenditures for outpatient visits in India and China, and higher expenditures for hospital visits in Russia. Medicines constituted the largest proportion of out-of-pocket expenditures in persons with multimorbidity (88.3% for outpatient, 55.9% for inpatient visit in China) in most countries.
conclusionMultimorbidity is associated with higher levels of healthcare utilisation and greater financial burden for individuals in middle-income countries. Our study supports the WHO call for universal health insurance and health service coverage in LMICs, particularly for vulnerable groups such as the elderly with multimorbidity.
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