Evidence map›Paper›PMID 26153682›Full record

ArticleNutrients2015

Modifying Choroidal Neovascularization Development with a Nutritional Supplement in Mice.

Alina Adriana Ivanescu, Patricia Fernández-Robredo, Henar Heras-Mulero, Luis Manuel Sádaba-Echarri, Laura García-García, Vanessa Fernández-García, Maite Moreno-Orduna, Aitor Redondo-Exposito, Sergio Recalde, Alfredo García-Layana

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  11. Targeting Lipid Metabolism for the Treatment of Age-Related Macular Degeneration: Insights from Preclinical Mouse Models.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Alina Adriana IvanescuExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. henarheras@yahoo.es.
Patricia Fernández-RobredoExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. mgarcia.6@alumni.unav.es.
Henar Heras-MuleroDepartment of Ophthalmology, Hospital Virgen del Camino, Servicio Navarro de Salud, Irunlarrea 4 Street, 31008 Pamplona, Spain. henarheras@yahoo.es.
Luis Manuel Sádaba-EcharriIdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain. lmsadaba@unav.es.
Laura García-GarcíaExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. mgarcia.6@alumni.unav.es.
Vanessa Fernández-GarcíaExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. vfernandez87@hotmail.es.
Maite Moreno-OrdunaExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. maimoreno@unav.es.
Aitor Redondo-ExpositoExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. aredondo.5@alumni.unav.es.
Sergio RecaldeExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. aglayana@unav.es.
Alfredo García-LayanaExperimental Ophthalmology Laboratory, School of Medicine, University of Navarra, Irunlarrea s/n Street, Los Castaños Building 31008 Pamplona, Spain. lmsadaba@unav.es.
Universidad de Navarra · ESNavarre Institute of Health Research · ESHospital Virgen del Camino · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the effect of nutritional supplements (modified Age Related Eye Disease Study (AREDS)-II formulation containing vitamins, minerals, lutein, resveratrol, and omega-3 fatty acids) on choroidal neovascularization (CNV). Supplements were administered alone and combined with intravitreal anti-VEGF in an early-CNV (diode laser-induced) murine model. Sixty mice were evenly divided into group V (oral vehicle, intravitreal saline), group S (oral supplement, intravitreal saline), group V + aVEGF (oral vehicle, intravitreal anti-VEGF), and group S + aVEGF (oral supplement, intravitreal anti-VEGF). Vehicle and nutritional supplements were administered daily for 38 days beginning 10 days before laser. Intravitreal injections were administered 48 h after laser. Fluorescein angiography (FA) and flat-mount CD31 staining evaluated leakage and CNV lesion area. Expression of VEGF, MMP-2 and MMP-9 activity, and NLRP3 were evaluated with RT-PCR, zymography, and western-blot. Leakage, CNV size, VEGF gene and protein expression were lower in groups V + aVEGF, S + aVEGF, and S than in V (all p < 0.05). Additionally, MMP-9 gene expression differed between groups S + aVEGF and V (p < 0.05) and MMP-9 activity was lower in S + aVEGF than in V and S (both p < 0.01). Levels of MMP-2 and NLRP3 were not significantly different between groups. Nutritional supplements either alone or combined with anti-VEGF may mitigate CNV development and inhibit retinal disease involving VEGF overexpression and CNV.

Indexed as

Dietary SupplementsAnimalsCarrier ProteinsChoroidChoroidal NeovascularizationDisease Models, AnimalDrug Therapy, CombinationFatty Acids, Omega-3Fluorescein AngiographyIntravitreal InjectionsLuteinMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMineralsNLR Family, Pyrin Domain-Containing 3 ProteinCarrier ProteinsFatty Acids, Omega-3LuteinMatrix Metalloproteinase 2Matrix Metalloproteinase 9MineralsNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseResveratrolStilbenesVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVitaminsantioxidantsanti-VEGFchoroidal neovascularisationmouse model

Identifiers

PMID26153682
PMCPMC4517006
OpenAlexW1651971811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.