ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2015
Elemental mapping of the entire intact Drosophila gastrointestinal tract.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Divalent metal content in diet affects severity of manganese toxicity in Drosophila.Biology open · 2024Article
- A Comprehensive Review on the Roles of Metals Mediating Insect-Microbial Pathogen Interactions.Metabolites · 2023Review
- Tryptophan regulatesProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nano/microparticles in conjunction with microalgae extract as novel insecticides against Mealworm beetles, Tenebrio molitor.Scientific reports · 2021Article
- Dietary zinc enrichment reduces the cadmium burden of mealworm beetle (Tenebrio molitor) larvae.Scientific reports · 2020Article
- Impact of Autophagy and Aging on Iron Load and Ferritin inFrontiers in cell and developmental biology · 2019Article
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- Biogenesis of zinc storage granules inThe Journal of experimental biology · 2018Article
- Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis inG3 (Bethesda, Md.) · 2018Article
- Elemental Contrast X-ray Tomography Using Ross Filter Pairs with a Polychromatic Laboratory Source.Scientific reports · 2017Article
- Article
- Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- Ferritin Assembly in Enterocytes of Drosophila melanogaster.International journal of molecular sciences · 2016Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main role of the animal gastrointestinal (GI) tract is the selective absorption of dietary nutrients from ingested food sources. One class of vital micronutrients are the essential biometals such as copper, zinc and iron, which participate in a plethora of biological process, acting as enzymatic or structural co-factors for numerous proteins and also as important cellular signalling molecules. To help elucidate the mechanisms by which biometals are absorbed from the diet, we mapped elemental distribution in entire, intact Drosophila larval GI tracts using synchrotron X-ray fluorescence microscopy. Our results revealed distinct regions of the GI tract enriched for specific metals. Copper was found to be concentrated in the copper cell region but also in the region directly anterior to the copper cells and unexpectedly, in the middle midgut/iron cell region as well. Iron was observed exclusively in the iron cell region, confirming previous work with iron-specific histological stains. Zinc was observed throughout the GI tract with an increased accumulation in the posterior midgut region, while manganese was seen to co-localize with calcium specifically in clusters in the distal Malpighian tubules. This work simultaneously reveals distribution of a number of biologically important elements in entire, intact GI tracts. These distributions revealed not only a previously undescribed Ca/Mn co-localization, but also the unexpected presence of additional Cu accumulations in the iron cell region.
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