Trial reportAnnals of neurology2015
Time to endovascular reperfusion and degree of disability in acute stroke.
Trial report in Annals of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 5 syntheses or guidelines pooled it, 185 citations in OpenAlex.
- Advancing stroke diagnosis and management through nuclear medicine: a systematic review of clinical trials.Frontiers in medicine · 2024Pooled it
- Sex Differences in Outcome After Endovascular Stroke Therapy for Acute Ischemic Stroke.Stroke · 2019Pooled it
- General Anesthesia Versus Conscious Sedation for Intracranial Mechanical Thrombectomy: A Systematic Review and Meta-analysis of Randomized Clinical Trials.Journal of the American Heart Association · 2019Pooled it
- Stent-Retriever Thrombectomy for Acute Anterior Ischemic Stroke with Tandem Occlusion: A Systematic Review and Meta-Analysis.European radiology · 2017Pooled it
- Mechanical thrombectomy for emergent large vessel occlusion: a critical appraisal of recent randomized controlled clinical trials.Brain and behavior · 2016Pooled it
- Normobaric Hyperoxia in Patients With Acute Stroke: Enhancing Neuroprotection Through Inhibition of Inflammation.Journal of the American Heart Association · 2026Trial
- Automated Large Vessel Occlusion Detection Software and Thrombectomy Treatment Times: A Cluster Randomized Clinical Trial.JAMA neurology · 2023Trial
- Current status of a helicopter transportation system on remote islands for patients undergoing mechanical thrombectomy.PloS one · 2021Trial
- Brain Emergency Management Initiative (BEMI-S): Assessment of Embolectomy Transfer Times Using a Novel Stroke System Transfer Protocol.Neurology. Clinical practice · 2026Article
- The comparison of MRI and CT protocol examination times for mechanical thrombectomy in acute ischemic stroke.Radiological physics and technology · 2025Article
- Ischemic Stroke Lesion Core Segmentation from CT Perfusion Scans Using Attention ResUnet Deep Learning.Journal of imaging informatics in medicine · 2025Article
- STEMI to stroke: bridging the stroke gap by cross-training interventional cardiologists.Annals of medicine and surgery (2012) · 2025Article
- Endovascular therapy compared to best medical treatment in Non-ATTENTION patients: a multicenter registry study.BMC neurology · 2025Article
- Detection of GFAP and D-Dimer in a Point-of-Care Test for Large Vessel Occlusion Ischemic Stroke.Stroke (Hoboken, N.J.) · 2025Article
- Non-Contrast Computed Tomography-Based Triage and Notification for Large Vessel Occlusion Stroke: A Before and After Study Utilizing Artificial Intelligence on Treatment Times and Outcomes.Journal of clinical medicine · 2025Article
- Article
- DSA-based perfusion parameters versus TICI score after mechanical thrombectomy in acute ischaemic stroke patients: a congruence analysis.European radiology experimental · 2024Article
- Nose-to-brain delivery of stem cells in stroke: the role of extracellular vesicles.Stem cells translational medicine · 2024Review
- Large vessel occlusion detection by non-contrast CT using artificial ıntelligence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Emergency Carotid Thrombo-Endarterectomy after Failed Endovascular Recanalization for Acute Complete Carotid Occlusion: A Case Report.Brain sciences · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
objectiveFaster time from onset to recanalization (OTR) in acute ischemic stroke using endovascular therapy (ET) has been associated with better outcome. However, previous studies were based on less-effective first-generation devices, and analyzed only dichotomized disability outcomes, which may underestimate the full effect of treatment.
methodsIn the combined databases of the SWIFT and STAR trials, we identified patients treated with the Solitaire stent retriever with achievement of substantial reperfusion (Thrombolysis in Cerebral Infarction [TICI] 2b-3). Ordinal numbers needed to treat values were derived by populating joint outcome tables.
resultsAmong 202 patients treated with ET with TICI 2b to 3 reperfusion, mean age was 68 (±13), 62% were female, and median National Institutes of Health Stroke Scale (NIHSS) score was 17 (interquartile range [IQR]: 14-20). Day 90 modified Rankin Scale (mRS) outcomes for OTR time intervals ranging from 180 to 480 minutes showed substantial time-related reductions in disability across the entire outcome range. Shorter OTR was associated with improved mean 90-day mRS (1.4 vs. 2.4 vs. 3.3, for OTR groups of 124-240 vs. 241-360 vs. 361-660 minutes; p < 0.001). The number of patients identified as benefitting from therapy with shorter OTR were 3-fold (range, 1.5-4.7) higher on ordinal, compared with dichotomized analysis. For every 15-minute acceleration of OTR, 34 per 1,000 treated patients had improved disability outcome.
interpretationAnalysis of disability over the entire outcome range demonstrates a marked effect of shorter time to reperfusion upon improved clinical outcome, substantially higher than binary metrics. For every 5-minute delay in endovascular reperfusion, 1 of 100 patients has a worse disability outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.