ArticleDevelopment (Cambridge, England)2015
C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- PHA-4/FoxA controls the function of pharyngeal and extrapharyngeal enteric neurons inGenes & development · 2026Article
- Early nervous system development in the chaetognathFrontiers in cell and developmental biology · 2026Article
- The Charcot-Marie-Tooth Neuropathy (CMTX3) Complex Structural Variation Causes Differential SOX3 Spatiotemporal Expression.Human mutation · 2026Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- MAB-5/Hox regulates the Q neuroblast transcriptome, including cwn-1/Wnt, to mediate posterior migration in Caenorhabditis elegans.Genetics · 2024Article
- SoxB family genes delay regeneration and cause abnormal movement in Dugesia japonica.Molecular genetics and genomics : MGG · 2024Article
- Expanded expression of pro-neurogenic factor SoxB1 during larval development of gastropodFrontiers in neuroscience · 2024Article
- Characterization of Schistosome Sox Genes and Identification of a Flatworm Class of Sox Regulators.Pathogens (Basel, Switzerland) · 2023Article
- The CCAAT-box transcription factor, NF-Y complex, mediates the specification of the IL1 neurons in C. elegans.BMB reports · 2023Article
- Stem cell proliferation and differentiation during larval metamorphosis of the model tapewormFrontiers in cellular and infection microbiology · 2023Article
- A natural transdifferentiation event involving mitosis is empowered by integrating signaling inputs with conserved plasticity factors.Cell reports · 2022Article
- Article
- Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification.PLoS genetics · 2022Article
- Homeobox genes and the specification of neuronal identity.Nature reviews. Neuroscience · 2021Review
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
- Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans.Development (Cambridge, England) · 2021Article
- Structural Analysis of theFrontiers in neuroanatomy · 2021Article
- Article
- Combining single-cell RNA-sequencing with a molecular atlas unveils new markers for Caenorhabditis elegans neuron classes.Nucleic acids research · 2020Article
- Investigating cellular and molecular mechanisms of neurogenesis in Capitella teleta sheds light on the ancestor of Annelida.BMC evolutionary biology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Neurogenesis involves deeply conserved patterning molecules, such as the proneural basic helix-loop-helix transcription factors. Sox proteins and specifically members of the SoxB and SoxC groups are another class of conserved transcription factors with an important role in neuronal fate commitment and differentiation in various species. In this study, we examine the expression of all five Sox genes of the nematode C. elegans and analyze the effect of null mutant alleles of all members of the SoxB and SoxC groups on nervous system development. Surprisingly, we find that, unlike in other systems, neither of the two C. elegans SoxB genes sox-2 (SoxB1) and sox-3 (SoxB2), nor the sole C. elegans SoxC gene sem-2, is broadly expressed throughout the embryonic or adult nervous system and that all three genes are mostly dispensable for embryonic neurogenesis. Instead, sox-2 is required to maintain the developmental potential of blast cells that are generated in the embryo but divide only postembryonically to give rise to differentiated neuronal cell types. Moreover, sox-2 and sox-3 have selective roles in the terminal differentiation of specific neuronal cell types. Our findings suggest that the common themes of SoxB gene function across phylogeny lie in specifying developmental potential and, later on, in selectively controlling terminal differentiation programs of specific neuron types, but not in broadly controlling neurogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.