Evidence map›Paper›PMID 26153146›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2015

iROLL: does 3-D radioguided occult lesion localization improve surgical management in early-stage breast cancer?

Christina Bluemel, Andreas Cramer, Christoph Grossmann, Georg W Kajdi, Uwe Malzahn, Nora Lamp, Heinz-Jakob Langen, Jan Schmid, Andreas K Buck, Hanns-Jörg Grimminger and 1 more

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. The current role of nuclear medicine in breast cancer.The British journal of radiology · 2023
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Christina BluemelDepartment of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany. Bluemel_c@ukw.de.
Andreas CramerDepartment of Obstetrics and Gynecology, Missionsärztliches Klinikum Würzburg, Würzburg, Germany.
Christoph GrossmannDepartment of Obstetrics and Gynecology, Missionsärztliches Klinikum Würzburg, Würzburg, Germany.
Georg W KajdiDepartment of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Uwe MalzahnInstitute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Nora LampInstitute of Pathology, University of Würzburg, Würzburg, Germany.
Heinz-Jakob LangenDepartment of Radiology, Missionsärztliches Klinikum Würzburg, Würzburg, Germany.
Jan SchmidDepartment of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Hanns-Jörg GrimmingerDepartment of Obstetrics and Gynecology, Missionsärztliches Klinikum Würzburg, Würzburg, Germany.
Ken HerrmannDepartment of Nuclear Medicine, University Hospital of Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Germany.
Universitätsklinikum Würzburg · DEKlinikum Würzburg Mitte · DEUniversity of Würzburg · DEMedical Mission Institute · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo prospectively evaluate the feasibility of 3-D radioguided occult lesion localization (iROLL) and to compare iROLL with wire-guided localization (WGL) in patients with early-stage breast cancer undergoing breast-conserving surgery and sentinel lymph node biopsy (SLNB).

methodsWGL (standard procedure) and iROLL in combination with SLNB were performed in 31 women (mean age 65.1 ± 11.2 years) with early-stage breast cancer and clinically negative axillae. Patient comfort in respect of both methods was assessed using a ten point scale. SLNB and iROLL were guided by freehand SPECT (fhSPECT). The results of the novel 3-D image-based method were compared with those of WGL, ultrasound-based lesion localization, and histopathology.

resultsiROLL successfully detected the malignant primary and at least one sentinel lymph node in 97% of patients. In a single patient (3%), only iROLL, and not WGL, enabled lesion localization. The variability between fhSPECT and ultrasound-based depth localization of breast lesions was low (1.2 ± 1.4 mm). Clear margins were achieved in 81% of the patients; however, precise prediction of clear histopathological surgical margins was not feasible using iROLL. Patients rated iROLL as less painful than WGL with a pain score 0.8 ± 1.2 points (p < 0.01) lower than the score for iROLL.

conclusioniROLL is a well-tolerated and feasible technique for localizing early-stage breast cancer in the course of breast-conserving surgery, and is a suitable replacement for WGL. As a single image-based procedure for localization of breast lesions and sentinel nodes, iROLL may improve the entire surgical procedure. However, no advantages of the image-guided procedure were found with regard to prediction of complete tumour resection.

Indexed as

Imaging, Three-DimensionalAdultAgedAged, 80 and overBreast NeoplasmsFemaleHumansMastectomy, SegmentalMiddle AgedNeoplasm StagingSentinel Lymph Node BiopsyTomography, Emission-Computed, Single-PhotonTreatment Outcome

Identifiers

PMID26153146
OpenAlexW797829207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.