ArticleScientific reports2015
Mining microbial metatranscriptomes for expression of antibiotic resistance genes under natural conditions.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Trial
- Fosfomycin Resistance: An Update on the Anthropogenic Impact Through Agriculture.Pathogens (Basel, Switzerland) · 2025Review
- Nanoparticle-mediated approaches to combat antibiotic resistance: a comprehensive review on current progress, mechanisms, and future perspectives.RSC advances · 2025Review
- Multi-omics surveillance of antimicrobial resistance in the pig gut microbiome.Animal microbiome · 2025Article
- Biosynthetic Gene Clusters from Swine Gut Microbiome.Microorganisms · 2023Article
- Review
- metaGEM: reconstruction of genome scale metabolic models directly from metagenomes.Nucleic acids research · 2021Article
- Influence of Human Eating Habits on Antimicrobial Resistance Phenomenon: Aspects of Clinical Resistome of Gut Microbiota in Omnivores, Ovolactovegetarians, and Strict Vegetarians.Antibiotics (Basel, Switzerland) · 2021Article
- Enrichment of antibiotic resistance genes (ARGs) in polyaromatic hydrocarbon-contaminated soils: a major challenge for environmental health.Environmental science and pollution research international · 2021Review
- Diverse and abundant resistome in terrestrial and aquatic vertebrates revealed by transcriptional analysis.Scientific reports · 2020Article
- From the Pipeline to the Bedside: Advances and Challenges in Clinical Metagenomics.The Journal of infectious diseases · 2020Review
- Characterization of antibiotic resistance and host-microbiome interactions in the human upper respiratory tract during influenza infection.Microbiome · 2020Article
- Functional dynamics of bacterial species in the mouse gut microbiome revealed by metagenomic and metatranscriptomic analyses.PloS one · 2020Article
- Article
- Article
- Meta-transcriptomics reveals a diverse antibiotic resistance gene pool in avian microbiomes.BMC biology · 2019Article
- Article
- Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria.Antimicrobial resistance and infection control · 2019Article
- Comparative Metagenomics and Network Analyses Provide Novel Insights Into the Scope and Distribution of β-Lactamase Homologs in the Environment.Frontiers in microbiology · 2019Article
- Microbiome and infectivity studies reveal complex polyspecies tree disease in Acute Oak Decline.The ISME journal · 2018Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance genes are found in a broad range of ecological niches associated with complex microbiota. Here we investigated if resistance genes are not only present, but also transcribed under natural conditions. Furthermore, we examined the potential for antibiotic production by assessing the expression of associated secondary metabolite biosynthesis gene clusters. Metatranscriptome datasets from intestinal microbiota of four human adults, one human infant, 15 mice and six pigs, of which only the latter have received antibiotics prior to the study, as well as from sea bacterioplankton, a marine sponge, forest soil and sub-seafloor sediment, were investigated. We found that resistance genes are expressed in all studied ecological niches, albeit with niche-specific differences in relative expression levels and diversity of transcripts. For example, in mice and human infant microbiota predominantly tetracycline resistance genes were expressed while in human adult microbiota the spectrum of expressed genes was more diverse, and also included β-lactam, aminoglycoside and macrolide resistance genes. Resistance gene expression could result from the presence of natural antibiotics in the environment, although we could not link it to expression of corresponding secondary metabolites biosynthesis clusters. Alternatively, resistance gene expression could be constitutive, or these genes serve alternative roles besides antibiotic resistance.
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