Evidence map›Paper›PMID 26152596›Full record

ArticleScientific reports2015

Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene.

Qian Wang, Chao Liu, Chaoming Tang, Huiping Guo, Yujiao Liu, Lina Wang, Haichao Zhao, Yongliang Shang, Yang Wen, Yuan Lin and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Qian Wang1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Chao Liu1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Chaoming Tang1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Huiping GuoState Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Yujiao Liu1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] College of Marine Life, Ocean University of China, Qingdao 266003, China.
Lina Wang1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Haichao Zhao1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Yongliang Shang1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Yang WenState Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China.
Yuan LinState Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China.
Tao ZhouState Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China.
Zuomin Zhou1] State Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China [2] Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China.
Wen DongCollege of Marine Life, Ocean University of China, Qingdao 266003, China.
Zhibin HuState Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China.
Xuejiang Guo1] State Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China [2] Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China.
Jiahao Sha1] State Key Laboratory of Reproductive Medicine, Collaborative Innovation Center of Genetics and Development, Nanjing Medical University, Nanjing 210029, China [2] Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China.
Wei Li1] State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2] University of Chinese Academy of Sciences, Beijing 100049, China.
Nanjing Medical University · CNInstitute of Zoology · CNChinese Academy of Sciences · CNOcean University of China · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately ten percent of male infertility is caused by non-obstructive azoospermia (NOA), but the etiologies of many NOA remain elusive. Recently, a genome-wide association study (GWAS) of NOA in Han Chinese men was conducted, and only a few genetic variants associated with NOA were found, which might have resulted from genetic heterogeneity. However, those variants that lack genome-wide significance might still be essential for fertility. Functional analysis of genes surrounding these variants in Drosophila identified some spermatogenesis-essential genes. As a complementary method of Drosophila screening, SK1 background Saccharomvces cerevisiae was used as a model to screen meiosis-related genes from the NOA GWAS data in this study. After functional screening, GDA1 (orthologous to humanENTPD6) was found to be a novel meiosis-related gene. The deletion of GDA1 resulted in the failure of yeast sporulation. Further investigations showed that Gda1p was important for pre-meiotic S phase entry. Interestingly, the meiotic role of Gda1p was dependent on its guanosine diphosphatase activity, but not it's cytoplasmic, transmembrane or stem domains. These yeast data suggest that ENTPD6 may be a novel meiosis-associated NOA-related gene, and the yeast model provides a good approach to analyze GWAS results of NOA.

Indexed as

AzoospermiaGenome-Wide Association StudyGlycosylationHumansMaleMeiosisNuclear ProteinsPolymorphism, Single NucleotidePyrophosphatasesReal-Time Polymerase Chain ReactionRNA, MessengerSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS PhaseTranscription FactorsENTPD6 protein, humanguanosine-diphosphataseIME1 protein, S cerevisiaeNuclear ProteinsPyrophosphatasesRNA, MessengerSaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID26152596
PMCPMC4495445
OpenAlexW2254009899

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.