ArticlePeritoneal dialysis international : journal of the International Society for Peritoneal Dialysis2015
The Effect of Fluid Overload on Clinical Outcome in Southern Chinese Patients Undergoing Continuous Ambulatory Peritoneal Dialysis.
Article in Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05721404 (Icodextrin Postpones the Shift of Low Dose to Full Dose Dialysis in the First Year of Incremental Peritoneal Dialysis), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Icodextrin Postpones the Shift of Low Dose to Full Dose Dialysis in the First Year of Incremental Peritoneal Dialysis: A Randomized Controlled Trial
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of bioimpedance-defined overhydration parameters on mortality and cardiovascular events in patients undergoing dialysis: a systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis.Scientific reports · 2018Pooled it
- Bioelectrical impedance analysis as a nutritional assessment tool in Autosomal Dominant Polycystic Kidney Disease.PloS one · 2019Trial
- Increased Extracellular-to-Total Body Water Ratio in Community-Dwelling Individuals in their 20s to 90s is Associated with Decreased Grip Strength and Gait Speed.Annals of geriatric medicine and research · 2026Article
- Association between preoperative extracellular water-to-total body water ratio and time to walking independence after total hip arthroplasty: a retrospective cohort study.International orthopaedics · 2026Article
- Management of Hypertension in Patients Undergoing Peritoneal Dialysis: A Narrative Review.Cureus · 2026Review
- A Prospective Study of Lipid Profile in Incident Patients on Peritoneal Dialysis.Arquivos brasileiros de cardiologia · 2026Article
- Peritoneal protein clearance, fluid overload, and cardiovascular events in patients undergoing peritoneal dialysis: a prospective cohort study.Renal failure · 2025Article
- Risk factors for the development of intradialytic hypotension in patients undergoing maintenance hemodialysis.International urology and nephrology · 2025Article
- Hidden Impacts of Peritoneal Dialysis on the Endocrine System.Life (Basel, Switzerland) · 2025Review
- Impact of glycemic control on residual kidney function and technique failure associated with volume overload in diabetic patients on peritoneal dialysis.Kidney research and clinical practice · 2025Article
- Nontraditional Factors Influencing Cardiovascular Disease Risk: Correlation Among Framingham Risk Score, Body Composition Index, and Sleep-Breathing Monitoring Index.Clinical and translational science · 2025Article
- Predictors and prognostic significance of the volume load trajectory: a longitudinal study in patients on peritoneal dialysis.Renal failure · 2024Article
- Application of Bioelectrical Impedance Analysis in Nutritional Management of Patients with Chronic Kidney Disease.Nutrients · 2023Review
- Clinical usefulness of phase angle as an indicator of muscle wasting and malnutrition in inpatients with cardiovascular diseases.Asia Pacific journal of clinical nutrition · 2023Article
- Pathophysiological concepts and screening of cardiovascular disease in dialysis patients.Frontiers in nephrology · 2023Review
- Use of the systemic inflammation response index (SIRI) as a novel prognostic marker for patients on peritoneal dialysis.Renal failure · 2022Article
- Impact of fluid overload on blood pressure variability in patients on peritoneal dialysis.Renal failure · 2022Article
- Lipidic profiles of patients starting peritoneal dialysis suggest an increased cardiovascular risk beyond classical dyslipidemia biomarkers.Scientific reports · 2022Observational
- Optimization of the Chronic Kidney Disease-Peritoneal Dialysis App to Improve Care for Patients on Peritoneal Dialysis in Northeast Thailand: User-Centered Design Study.JMIR formative research · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled♦
backgroundFluid overload is frequently present in dialysis patients and one of the important predictors of patient outcome. This study aimed to investigate the influence of fluid overload on all-cause mortality and technique failure in Southern Chinese continuous ambulatory peritoneal dialysis (CAPD) patients. ♦
methodsThis was a post hoc study from a cross-sectional survey originally designed to investigate the prevalence and associated risk factors of fluid overload defined by bioimpedance analysis (BIA) in CAPD patients from January 1, 2008, to December 31, 2009. All 307 CAPD patients completing the original study were followed up until December 31, 2012. ♦
resultsWith a median follow-up period of 38.4 (19.2 - 47.9) months, 52 patients died. Patients with fluid overload (defined by extracellular water/total body water [ECW/TBW] ≥ 0.40) had a significantly higher peritonitis rate (0.016 vs 0.011 events/month exposure, p = 0.018) and cerebrovascular event rate (3.9 vs 1.1 events/100 patient years, p = 0.024) than the normal hydrated patients. Moreover, the results showed a significant rising of all-cause mortality (log-rank test = 5.59, p = 0.018), and a trend of increasing cardiovascular disease (CVD) mortality (log-rank test = 2.90, p = 0.089) and technique failure (log-rank test = 3.78, p = 0.052) in the patients with fluid overload. Fluid overload independently predicted all-cause mortality (hazard ratio [HR] = 12.98, 95%, confidence interval [CI] = 1.06 - 168.23, p = 0.042) and technique failure (HR = 13.56, 95% CI = 2.53 - 78.69, p = 0.007) in CAPD patients after adjustment for confounders. ♦
conclusionsFluid overload defined by BIA was an independent predictor for all-cause mortality and technique failure in CAPD patients. Continuous ambulatory peritoneal dialysis patients with fluid overload had a higher peritonitis rate, cardiovascular event rate, and poorer clinical outcome than those patients with normal hydration.
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