ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2015
Loci, genes, and mechanisms associated with tolerance to ferrous iron toxicity in rice (Oryza sativa L.).
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Use of Humic Acids, Zeolite and Bentonite to Mitigate Iron Toxicity and Improve Growth Parameters and Chemical Composition in Maize (Molecules (Basel, Switzerland) · 2026Article
- Genomic dissection of iron toxicity tolerance in rice identifies key loci, candidate genes, and associated haplotypes.Scientific reports · 2026Article
- Carotenoid biosynthesis drives root plasticity through aerenchyma and iron plaque formation in rice.Nature plants · 2026Article
- Elemental profiling reveals rhizosphere oxidation-mediated selective Fe exclusion mechanisms against Fe toxicity in rice in Madagascar.Plant and soil · 2026Article
- Genetic variation in leaf bronzing and dry matter production of rice varieties as indicators of tolerance to iron toxicity.Breeding science · 2025Article
- The Role of Organic Materials in Shaping the Content of Trace Elements in Iron-Contaminated Soil.Materials (Basel, Switzerland) · 2025Article
- Candidate Genes and Favorable Haplotypes Associated with Iron Toxicity Tolerance in Rice.International journal of molecular sciences · 2024Article
- You can't always get as much iron as you want: how rice plants deal with excess of an essential nutrient.Frontiers in plant science · 2024Review
- Magnesium supply alleviates iron toxicity-induced leaf bronzing in rice through exclusion and tissue-tolerance mechanisms.Frontiers in plant science · 2023Article
- Determination of traits responding to iron toxicity stress at different stages and genome-wide association analysis for iron toxicity tolerance in rice (Frontiers in plant science · 2022Article
- Raman Spectroscopy Enables Non-invasive and Confirmatory Diagnostics of Aluminum and Iron Toxicities in Rice.Frontiers in plant science · 2022Article
- Genome-Wide Association Study of Local Thai Indica Rice Seedlings Exposed to Excessive Iron.Plants (Basel, Switzerland) · 2021Article
- Using natural variation to understand plant responses to iron availability.Journal of experimental botany · 2021Article
- Population genetic structure and association mapping for iron toxicity tolerance in rice.PloS one · 2021Article
- Evaluation of rice wild relatives as a source of traits for adaptation to iron toxicity and enhanced grain quality.PloS one · 2020Article
- Multiple Small-Effect Alleles ofFrontiers in plant science · 2020Article
- GSNOR provides plant tolerance to iron toxicity via preventing iron-dependent nitrosative and oxidative cytotoxicity.Nature communications · 2019Article
- Tolerance of Iron-Deficient and -Toxic Soil Conditions in Rice.Plants (Basel, Switzerland) · 2019Review
- Potassium Ion Channel GeneFrontiers in plant science · 2019Article
- Genotype Variation in Rice (Frontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageA genome-wide association study in rice yielded loci and candidate genes associated with tolerance to iron toxicity, and revealed biochemical mechanisms associated with tolerance in contrasting haplotypes. Iron toxicity is a major nutrient disorder affecting rice. Therefore, understanding the genetic and physiological mechanisms associated with iron toxicity tolerance is crucial in adaptive breeding and biofortification. We conducted a genome-wide association study (GWAS) by exposing a population of 329 accessions representing all subgroups of rice to ferrous iron stress (1000 ppm, 5 days). Expression patterns and sequence polymorphisms of candidate genes were investigated, and physiological hypotheses related to candidate loci were tested using a subset of contrasting haplotypes. Both iron including and excluding tolerant genotypes were observed, and shoot iron concentrations explained around 15.5 % of the variation in foliar symptom formation. GWAS for seven traits yielded 20 SNP markers exceeding a significance threshold of -log10 P > 4.0, which represented 18 distinct loci. One locus mapped for foliar symptom formation on chromosome 1 contained two putative glutathione-S-transferases, which were strongly expressed under iron stress and showed sequence polymorphisms in complete linkage disequilibrium with the most significant SNP. Contrasting haplotypes for this locus showed significant differences in dehydroascorbate reductase activity, which affected the plants' redox status under iron stress. We conclude that maintaining foliar redox homeostasis under iron stress represented an important tolerance mechanism associated with a locus identified through GWAS.
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