ArticleParasites & vectors2015
Genetic similarities between Cyclospora cayetanensis and cecum-infecting avian Eimeria spp. in apicoplast and mitochondrial genomes.
Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 53 citations in OpenAlex.
- Persistence of protozoan parasites andApplied and environmental microbiology · 2026Article
- The influence of parasitic infection (Eimeria spp.) on bone and cartilage tissue in an animal model.Scientific reports · 2025Article
- Evaluation of aqueous chlorine and peracetic acid sanitizers to inactivate protozoa and bacteria of concern in agricultural water.Applied and environmental microbiology · 2025Article
- Evaluation of nuclear and mitochondrial phylogenetics for the subtyping of Cyclospora cayetanensis.Parasitology research · 2023Article
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- Development of a targeted amplicon sequencing method for genotypingFrontiers in microbiology · 2023Article
- Targeted next generation sequencing ofHeliyon · 2022Article
- Hastening Progress inMicroorganisms · 2022Article
- Development of a Molecular Marker Based on the Mitochondrial Genome for Detection ofMicroorganisms · 2022Article
- Life Cycle and Transmission ofMicroorganisms · 2022Review
- The Elusive Mitochondrial Genomes of Apicomplexa: Where Are We Now?Frontiers in microbiology · 2021Review
- Dynamically expressed genes provide candidate viability biomarkers in a model coccidian.PloS one · 2021Article
- ExploringGenes · 2020Review
- Molecular typing of Cyclospora cayetanensis in produce and clinical samples using targeted enrichment of complete mitochondrial genomes and next-generation sequencing.Parasites & vectors · 2020Article
- Review
- Development of a workflow for identification of nuclear genotyping markers for Cyclospora cayetanensis.Parasite (Paris, France) · 2020Article
- Review
- Mitochondrial Junction Region as Genotyping Marker for Cyclospora cayetanensis.Emerging infectious diseases · 2019Article
- Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China.Parasites & vectors · 2019Article
- Mitochondrial genome sequence variation as a useful marker for assessing genetic heterogeneity among Cyclospora cayetanensis isolates and source-tracking.Parasites & vectors · 2019Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclospora cayetanensis is an important cause for diarrhea in children in developing countries and foodborne outbreaks of cyclosporiasis in industrialized nations. To improve understanding of the basic biology of Cyclospora spp. and development of molecular diagnostic tools and therapeutics, we sequenced the complete apicoplast and mitochondrial genomes of C. cayetanensis.
methodsThe genome of one Chinese C. cayetanensis isolate was sequenced using Roche 454 and Illumina technologies. The assembled genomes of the apicoplast and mitochondrion were retrieved, annotated, and compared with reference genomes for other apicomplexans to infer genome organizations and phylogenetic relationships. Sequence variations in the mitochondrial genome were identified by comparison of two C. cayetanensis nucleotide sequences from this study and a recent publication.
resultsThe apicoplast and mitochondrial genomes of C. cayetanensis are 34,155 and 6,229 bp in size and code for 65 and 5 genes, respectively. Comparative genomic analysis showed high similarities between C. cayetanensis and Eimeria tenella in both genomes; they have 85.6% and 90.4% nucleotide sequence similarities, respectively, and complete synteny in gene organization. Phylogenetic analysis of the genomic sequences confirmed the genetic similarities between cecum-infecting avian Eimeria spp. and C. cayetanensis. Like in other coccidia, both genomes of C. cayetanensis are transcribed bi-directionally. The apicoplast genome is circular, codes for the complete machinery for protein biosynthesis, and contains two inverted repeats that differ slightly in LSU rRNA gene sequences. In contrast, the mitochondrial genome has a linear concatemer or circular mapping topology. Eight single-nucleotide and one 7-bp multiple-nucleotide variants were detected between the mitochondrial genomes of C. cayetanensis from this and recent studies.
conclusionsThe apicoplast and mitochondrial genomes of C. cayetanensis are highly similar to those of cecum-infecting avian Eimeria spp. in both genome organization and sequences. The availability of sequence data beyond rRNA and heat shock protein genes could facilitate studies of C. cayetanensis biology and development of genotyping tools for investigations of cyclosporiasis outbreaks.
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