Evidence map›Paper›PMID 26152522›Full record

ArticleHernia : the journal of hernias and abdominal wall surgery2015

The effect of TISSEEL fibrin sealant on seroma formation following complex abdominal wall hernia repair: a single institutional review and derived cost analysis.

S C Azoury, N Rodriguez-Unda, K C Soares, C W Hicks, P A Baltodano, K E Poruk, Q L Hu, C M Cooney, P Cornell, K Burce and 1 more

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In one paragraph

Article in Hernia : the journal of hernias and abdominal wall surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. The use of adjuncts to reduce seroma in open incisional hernia repair: a systematic review.Hernia : the journal of hernias and abdominal wall surgery · 2018
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

S C AzouryDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA. sazoury1@jhmi.edu.ORCID http://orcid.org/0000-0002-2263-4149
N Rodriguez-UndaDepartment of Plastic and Reconstructive Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
K C SoaresDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA.
C W HicksDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA.
P A BaltodanoDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA.
K E PorukDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA.
Q L HuSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
C M CooneyDepartment of Plastic and Reconstructive Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
P CornellDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA.
K BurceDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA.
F E EckhauserDepartment of Surgery, The Johns Hopkins Hospital, Johns Hopkins University, School of Medicine, 600 N. Wolfe Street, Blalock 618, Baltimore, MD, 21287, USA. feckhau2@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe authors evaluated the ability of a fibrin sealant (TISSEEL™: Baxter Healthcare Corp, Deerfield, IL, USA) to reduce the incidence of post-operative seroma following abdominal wall hernia repair.

methodsWe performed a 4-year retrospective review of patients undergoing abdominal wall hernia repair, with and without TISSEEL, by a single surgeon (FEE) at The Johns Hopkins Hospital. Demographics, surgical risk factors, operative data and 30-day outcomes, including wound complications and related interventions, were compared. The quantity and cost of Tisseel per case was reviewed.

resultsA total of 250 patients were evaluated: 127 in the TISSEEL group and 123 in the non-TISSEEL control group. The average age for both groups was 56.6 years (P = 0.97). The majority of patients were female (TISSEEL 52.8%, non-TISSEEL 56.1%, P = 0.59) and ASA Class III (TISSEEL 56.7%, non-TISSEEL 58.5%, P = 0.40). There was no difference in the average defect size for both groups (TISSEEL 217 ± 187.6 cm(2), non-TISSEEL 161.3 ± 141.5 cm(2), P = 0.36). Surgical site occurrences occurred in 18.1% of the TISSEEL and 13% of the non-TISSEEL group (P = 0.27). There was a trend towards an increased incidence of seroma in the TISSEEL group (TISSEEL 11%, non-TISSEEL 4.9%, P = 0.07). A total of $124,472.50 was spent on TISSEEL, at an average cost of $995.78 per case.

conclusionsIn the largest study to date, TISSEEL™ application offered no advantage for the reduction of post-operative seroma formation following complex abdominal hernia repair. Moreover, the use of this sealant was associated with significant costs.

Indexed as

Abdominal WallAdultAgedCosts and Cost AnalysisFemaleFibrin Tissue AdhesiveHernia, VentralHerniorrhaphyHumansMaleMiddle AgedRetrospective StudiesSeromaWound HealingFibrin Tissue AdhesiveAbdominal wallFibrin sealantHerniaSeromaTISSEEL

Identifiers

PMID26152522
OpenAlexW757740745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.