ArticleMolecular genetics and genomics : MGG2016
Evolution and conservation of JmjC domain proteins in the green lineage.
Article in Molecular genetics and genomics : MGG, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Review
- Finding balance: the dynamic interplay between H3K27me3 writers and erasers in regulating environmental plasticity and memory.The New phytologist · 2026Review
- Histone demethylation by JMJ family genes: insights into plant growth and adaptation.Plant molecular biology · 2025Review
- JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis.Journal of translational medicine · 2025Article
- The H3K4 demethylase JMJ1 is required for proper timing of flowering in Brachypodium distachyon.The Plant cell · 2024Article
- Beyond NPK: Mineral Nutrient-Mediated Modulation in Orchestrating Flowering Time.Plants (Basel, Switzerland) · 2023Review
- MoJMJD6, a Nuclear Protein, Regulates Conidial Germination and Appressorium Formation at the Early Stage of Pathogenesis in Magnaporthe oryzae.The plant pathology journal · 2023Article
- Redox status of the plant cell determines epigenetic modifications under abiotic stress conditions and during developmental processes.Journal of advanced research · 2022Review
- Genome-wide identification and expression analysis of JmjC domain-containing genes in grape under MTA treatment.Functional & integrative genomics · 2022Article
- Genome-wide Characterization of the JmjC Domain-Containing Histone Demethylase Gene Family Reveals GhJMJ24 and GhJMJ49 Involving in Somatic Embryogenesis Process in Cotton.Frontiers in molecular biosciences · 2022Article
- Genome-wide identification, classification, and expression analysis of the JmjC domain-containing histone demethylase gene family in birch.BMC genomics · 2021Article
- JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance.Diabetes · 2021Article
- KSN heterozygosity is associated with continuous flowering of Rosa rugosa Purple branch.Horticulture research · 2021Article
- Systematic analysis of JmjC gene family and stress--response expression of KDM5 subfamily genes inPeerJ · 2021Article
- Characterization and Stress Response of the JmjC Domain-Containing Histone Demethylase Gene Family in the Allotetraploid Cotton SpeciesPlants (Basel, Switzerland) · 2020Article
- Genome-wide identification and functional analysis of JmjC domain-containing genes in flower development of Rosa chinensis.Plant molecular biology · 2020Article
- In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment.ACS medicinal chemistry letters · 2019Article
- Genome-wide identification, classification and expression analysis of the JmjC domain-containing histone demethylase gene family in maize.BMC genomics · 2019Article
- Influences of the Gut Microbiota on DNA Methylation and Histone Modification.Digestive diseases and sciences · 2017Review
- Genome-Wide Analysis of Soybean JmjC Domain-Containing Proteins Suggests Evolutionary Conservation Following Whole-Genome Duplication.Frontiers in plant science · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone modification regulates plant development events by epigenetically silencing or activating gene expression, and histone methylation is regulated by histone lysine methyltransferases (KMTs) and histone lysine demethylases (KDMs). The JmjC domain proteins, an important KDM family, erase methyl marks (CH3-) from histones and play key roles in maintaining homeostasis of histone methylation in vivo. Here, we analyzed 169 JmjC domain proteins from whole genomes of plants ranging from green alga to higher plants together with 36 from two animals (fruit fly and human). The plant JmjC domain proteins were divided into seven groups. Group-I KDM4/JHDM3 and Group-V JMJD6 were found in all the plant species and the other groups were detected mainly in vascular or seed plants. Group-I KDM4/JHDM3 was potentially associated with demethylation of H3K9me2/3, H3K27me2/3, and H3K36me1/2/3, Group-II KDM5A with H3K4me1/2/3, Group-III KDM5B with H3K4me1/2/3 and H3K9me1/2/3, Group-V JMJD6 with H3R2, H4R3, and hydroxylation of H4, and Group-VII KDM3/JHDM2 with H3K9me1/2/3. Group-IV/Group-VI JmjC domain-only A/B proteins were involved in hydroxylation and demethylation of unknown substrate sites. The binding sites for the cofactors Fe(II) and α-ketoglutarate in the JmjC domains also were analyzed. In the α-ketoglutarate binding sites, Thr/Phe/Ser and Lys were conserved and in the Fe(II) binding sites, two His and Glu/Asp were conserved. The results show that JmjC domain proteins are a conserved family in which domain organization and cofactor binding sites have been modified in some species. Our results provide insights into KDM evolution and lay a foundation for functional characterization of KDMs.
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