ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2016
APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles in African Americans.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04117204 (Identifying a Cardiorenal Protective Diet in a Lower-income African American Population With Chronic Kidney Disease at Risk for Cardiovascular Disease.), which is not on this map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Identifying a Cardiorenal Protective Diet in a Lower-income African American Population With Chronic Kidney Disease at Risk for Cardiovascular Disease.
Who cites it
19 citing papers in PubMed.
- Gut microbial features and circulating metabolomic signatures of frailty in older adults.Nature aging · 2024Article
- Metabolomic and Physiological Effects of a Cardiorenal Protective Diet Intervention in African American Adults with Chronic Kidney Disease.Metabolites · 2024Article
- Postdialysis serum phosphate equilibrium in hemodialysis patients on a controlled diet and no binders.Hemodialysis international. International Symposium on Home Hemodialysis · 2022Article
- Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury.PloS one · 2022Article
- Race, APOL1 Risk Variants, and Clinical Outcomes among Older Adults: The ARIC Study.Journal of the American Geriatrics Society · 2021Observational
- Lack of APOL1 in proximal tubules of normal human kidneys and proteinuric APOL1 transgenic mouse kidneys.PloS one · 2021Article
- Impact of early-life diet on long-term renal health.Molecular and cellular pediatrics · 2020Review
- APOL1 Nephropathy Risk Alleles and Mortality in African American Adults: A Cohort Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2020Article
- Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism.Scientific reports · 2019Article
- Association ofCirculation · 2019Article
- Ten years in: APOL1 reaches beyond the kidney.Current opinion in nephrology and hypertension · 2019Review
- The Impact of APOL1 on Chronic Kidney Disease and Hypertension.Advances in chronic kidney disease · 2019Review
- Article
- Kidney function is associated with an altered protein composition of high-density lipoprotein.Kidney international · 2017Article
- APOL1 Gene Kidney Risk Variants and Cardiovascular Disease: Getting to the Heart of the Matter.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Review
- Article
- How complicated can it be? The link between APOL1 risk variants and lipoprotein heterogeneity in kidney and cardiovascular diseases.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- Characterization of circulating APOL1 protein complexes in African Americans.Journal of lipid research · 2016Article
- The Apolipoprotein L1 Gene and Cardiovascular Disease.Methodist DeBakey cardiovascular journalReview
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundTwo independent coding variants in the apolipoprotein L1 gene (APOL1), G1 and G2, strongly associate with nephropathy in African Americans; associations with cardiovascular disease are more controversial. Although APOL1 binds plasma high-density lipoproteins (HDLs), data on APOL1 risk variant associations with HDL subfractions are sparse.
methodsTwo APOL1 G1 single nucleotide polymorphisms and the G2 insertion/deletion polymorphism were genotyped in 2010 Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study participants with nuclear magnetic resonance spectroscopy-based lipoprotein subfraction measurements. Linear regression was used to model associations between numbers of APOL1 G1/G2 risk variants and HDL subfractions, adjusting for demographic, clinical and ancestral covariates.
resultsFemale sex and higher percentage of African ancestry were positively associated with the number of APOL1 G1/G2 risk alleles. In the unadjusted analysis, mean (standard error) small HDL concentrations (μmol/L) for participants with zero, one and two G1/G2 risk alleles were 19.0 (0.2), 19.7 (0.2) and 19.9 (0.4), respectively (P = 0.02). Adjustment for age, sex, diabetes and African ancestry did not change the results but strengthened the statistical significance (P = 0.004). No significant differences in large or medium HDL, very low-density lipoprotein or low-density lipoprotein particle concentrations were observed by APOL1 genotype.
conclusionsGreater numbers of APOL1 G1/G2 risk alleles were associated with higher small HDL particle concentrations in African Americans. These results may suggest novel areas of investigation to uncover reasons for the association between APOL1 risk variants with adverse outcomes in African Americans.
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