ArticleScientific reports2015
Cortical dynamics and subcortical signatures of motor-language coupling in Parkinson's disease.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Towards affordable biomarkers of frontotemporal dementia: A classification study via network's information sharing.Scientific reports · 2017Trial
- Action and Event-Based Lexical-Semantic Processing in Parkinson's Disease.Language, cognition and neuroscience · 2026Article
- Longitudinal non-negative matrix factorization identifies the altered trajectory of motor symptoms in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Ecological Meanings: A Consensus Paper on Individual Differences and Contextual Influences in Embodied Language.Journal of cognition · 2023Article
- The embodied typist: Bimanual actions are modulated by words' implied motility and number of evoked limbs.PloS one · 2023Article
- Multidimensional inhibitory signatures of sentential negation in behavioral variant frontotemporal dementia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Alterations in resting-state functional connectivity after brain posterior lesions reflect the functionality of the visual system in hemianopic patients.Brain structure & function · 2022Article
- Multi-feature computational framework for combined signatures of dementia in underrepresented settings.Journal of neural engineering · 2022Article
- Multimodal Neurocognitive Markers of Naturalistic Discourse Typify Diverse Neurodegenerative Diseases.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Heart-brain interactions during social and cognitive stress in hypertensive disease: A multidimensional approach.The European journal of neuroscience · 2022Article
- Dementia ConnEEGtome: Towards multicentric harmonization of EEG connectivity in neurodegeneration.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Review
- The Neural Blending of Words and Movement: Event-Related Potential Signatures of Semantic and Action Processes during Motor-Language Coupling.Journal of cognitive neuroscience · 2021Article
- Functional connectivity of spoken language processing in early-stage Parkinson's disease: An MEG study.NeuroImage. Clinical · 2021Article
- Semantic Memory and Lexical Availability in Parkinson's Disease: A Statistical Learning Study.Frontiers in aging neuroscience · 2021Article
- The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science.Frontiers in neurology · 2021Review
- The Latin America and the Caribbean Consortium on Dementia (LAC-CD): From Networking to Research to Implementation Science.Journal of Alzheimer's disease : JAD · 2021Article
- Action Fluency in Parkinson's Disease: A Mini-Review and Viewpoint.Frontiers in aging neuroscience · 2021Review
- Time to Face Language: Embodied Mechanisms Underpin the Inception of Face-Related Meanings in the Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Motor-system dynamics during naturalistic reading of action narratives in first and second language.NeuroImage · 2020Article
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Authors and funding
15 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impairments of action language have been documented in early stage Parkinson's disease (EPD). The action-sentence compatibility effect (ACE) paradigm has revealed that EPD involves deficits to integrate action-verb processing and ongoing motor actions. Recent studies suggest that an abolished ACE in EPD reflects a cortico-subcortical disruption, and recent neurocognitive models highlight the role of the basal ganglia (BG) in motor-language coupling. Building on such breakthroughs, we report the first exploration of convergent cortical and subcortical signatures of ACE in EPD patients and matched controls. Specifically, we combined cortical recordings of the motor potential, functional connectivity measures, and structural analysis of the BG through voxel-based morphometry. Relative to controls, EPD patients exhibited an impaired ACE, a reduced motor potential, and aberrant frontotemporal connectivity. Furthermore, motor potential abnormalities during the ACE task were predicted by overall BG volume and atrophy. These results corroborate that motor-language coupling is mainly subserved by a cortico-subcortical network including the BG as a key hub. They also evince that action-verb processing may constitute a neurocognitive marker of EPD. Our findings suggest that research on the relationship between language and motor domains is crucial to develop models of motor cognition as well as diagnostic and intervention strategies.
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