ArticleBMC complementary and alternative medicine2015
Effect of Ampelopsis Radix on wound healing in scalded rats.
Article in BMC complementary and alternative medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 48 citations in OpenAlex.
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- Topical application of indigo-plant leaves extract enhances healing of skin lesion in an excision wound model in rats.Journal of applied biomedicine · 2022Article
- Luteolin is an Effective Component ofClinical, cosmetic and investigational dermatology · 2022Article
- Wound Healing and Antioxidant Properties of 80% Methanol Leaf Extract ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Enhanced healing of oral chemical burn by inhibiting inflammatory factors with an oral administration of shengFu oil.Frontiers in pharmacology · 2022Article
- Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation.Chinese medicine · 2021Article
- The Efficacy of Heat-Clearing (Qingre) and Detoxifying (Jiedu) Traditional Chinese Medicine Gargle for Chemotherapy-Induced Oral Mucositis: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2021Article
- Ethnobotanical Survey on Skin Whitening Prescriptions of Traditional Chinese Medicine in Taiwan.Frontiers in pharmacology · 2021Article
- Application of GC/MS-Based Metabonomic Profiling in Studying the Therapeutic Effects ofMolecules (Basel, Switzerland) · 2019Article
- AM-1241 CB2 Receptor Agonist Attenuates Inflammation, Apoptosis and Stimulate Progenitor Cells in Bile Duct Ligated Rats.Open access Macedonian journal of medical sciences · 2019Article
- Wound Healing and the Use of Medicinal Plants.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- The Wound Healing Effect ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- High-Fat Diet and Alcohol Intake Promotes Inflammation and Impairs Skin Wound Healing in Wistar Rats.Mediators of inflammation · 2018Article
- Wound Healing Effects ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Shengfu Oil Enhances the Healing of Full-Thickness Scalded Skin Accompanying the Differential Regulation of β-Catenin, Dlk1, and COX-2.Frontiers in pharmacology · 2017Article
- Article
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmpelopsis Radix has been used as a traditional Korean medicine for the treatment of burns and scalds. However, there has been no scientific research to date on the wound healing properties of Ampelopsis Radix for scald burns. This study aimed to evaluate the healing effect of Ampelopsis japonica root tuber ethanol extract (AJE) on induced cutaneous scald injury in Sprague Dawley (SD) rats.
methodsHot water scalds were induced in SD rats, who were then divided into the following 5 groups; 1) control group without treatment, 2) positive control group with 1% Silver sulfadiazine (SSD), 3) Vaseline group, and groups 4) and 5) that used Vaseline containing 5% and 20% AJE, respectively. The ointment was applied topically to the experimental rats, once daily for 21 days, starting at 24 h post induction of the scald injury. Gross examination, measurement of wound size, and histopathological examination were performed. And quantitative measurement of cytokine levels of tumor necrosis factor alpha (TNF-α), interleukin-10 (IL-10), transforming growth factor beta 1 (TGF-β1), and vascular endothelial growth factor (VEGF) were performed by enzyme-linked immunosorbent assay.
resultsClinical evaluation showed that the AJE and Vaseline groups, rapidly desquamated scab on day 12 post-scalding; in particular, the 20% AJE group achieved the greatest extent of skin recovery. Sizes of scald wound were significantly lower on days 12, 15, 18, and 21 in the AJE treated groups compared to the control groups. Histopathological evaluation showed a well-organized epithelial layer, angiogenesis, tissue granulation and collagen formation with the exception of inflammatory cells in the AJE-treated groups compared to the control groups on day 14, indicating that tissue regeneration had occurred. AJE treatment decreased TNF-α and increased IL-10 levels on days 2 and 14, indicating the anti-inflammatory action of AJE. The AJE groups also showed a decrease in TGF-β1 levels on day 7 and VEGF on day 14 in the serum of scald inflicted SD rat model.
conclusionsThese results suggest that AJE possesses scald wound healing activity via accelerating the scald wound repair during the inflammation and proliferative phases of the healing process.
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