ArticleEnvironmental health perspectives2016
Thyroid Antagonists (Perchlorate, Thiocyanate, and Nitrate) and Childhood Growth in a Longitudinal Study of U.S. Girls.
Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food.Nutrients · 2020Pooled it
- A Modified Iodine Balance Study to Explore the Recommended Nutrient Intake of Iodine in Chinese Preschool Children Aged 3 to 6 Years.Biological trace element research · 2026Trial
- Environmental exposure to perchlorate, nitrate, and thiocyanate in relation to myopia in adolescents: a cross-sectional NHANES study.European journal of medical research · 2026Article
- Thyroid peroxidase gene variants and autoimmunity in subclinical hypothyroidism: molecular mechanisms and clinical implications.Molecular biology reports · 2025Review
- Nitrate and Nitrite in the Diet: Protective and Harmful Effects in Health and Disease.Current nutrition reports · 2025Review
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- Article
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- The prevalence and determinants of diabetes mellitus and thyroid disorder comorbidity in Tabari cohort population.Scientific reports · 2024Article
- The association between perchlorate in drinking water and height and weight of children and adolescents in Southwest China: a retrospective cross-sectional study.Frontiers in public health · 2023Review
- Association of environmental exposure to perchlorate, nitrate, and thiocyanate with overweight/obesity and central obesity among children and adolescents in the United States of America using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016.New directions for child and adolescent development · 2022Article
- The association between environmental exposure to perchlorate, nitrate, and thiocyanate and all-cause and cause-specific mortality.Environmental science and pollution research international · 2022Article
- The Association Between Environmental Perchlorate, Nitrate, and Thiocyanate Exposure and Oral Pain in NHANES.Frontiers in public health · 2022Article
- Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.Breast cancer research : BCR · 2019Review
- Food Additives and Child Health.Pediatrics · 2018Article
- Urinary biomarkers of polycyclic aromatic hydrocarbons in pre- and peri-pubertal girls in Northern California: Predictors of exposure and temporal variability.Environmental research · 2018Article
- Phenol Concentrations During Childhood and Subsequent Measures of Adiposity Among Young Girls.American journal of epidemiology · 2017Article
- Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundPerchlorate, thiocyanate, and nitrate are sodium/iodide symporter (NIS) inhibitors that block iodide uptake into the thyroid, thus affecting thyroid function. Thyroid dysfunction can adversely affect somatic growth and development in children. To our knowledge, no studies have examined effects of NIS inhibitors on body size measures.
objectiveWe investigated associations between NIS inhibitors and childhood growth in 940 girls from the Puberty Study of the Breast Cancer and Environment Research Program.
methodsUrine samples collected from girls 6-8 years of age at enrollment (2004-2007) from New York City, greater Cincinnati, Ohio, and the Bay Area in California were analyzed for NIS inhibitors and creatinine (C). The longitudinal association between NIS inhibitors and anthropometric measures [height, waist circumference, and body mass index (BMI)] during at least three visits was examined using mixed effects linear models, adjusted for race and site.
resultsCompared with girls in the low-exposure group (3.6, 626, and 500 mg/gC, median perchlorate, thiocyanate, and nitrate, respectively) girls with the highest NIS inhibitor exposure (9.6, 2,343, and 955 mg/gC, median perchlorate, thiocyanate, and nitrate, respectively) had slower growth in waist circumference and BMI but not height. Significant differences in the predicted mean waist circumference and BMI between the low- and high-exposure groups were observed beginning at 11 years of age.
conclusionsHigher NIS inhibitor exposure biomarkers were associated with reductions in waist circumference and BMI. These findings underscore the need to assess exposure to NIS inhibitors with respect to their influence on childhood growth. CITATION: Mervish NA, Pajak A, Teitelbaum SL, Pinney SM, Windham GC, Kushi LH, Biro FM, Valentin-Blasini L, Blount BC, Wolff MS, for the Breast Cancer and Environment Research Project (BCERP). 2016. Thyroid antagonists (perchlorate, thiocyanate, and nitrate) and childhood growth in a longitudinal study of U.S. girls. Environ Health Perspect 124:542-549; http://dx.doi.org/10.1289/ehp.1409309.
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