Evidence map›Paper›PMID 26151922›Full record

ArticleTranslational psychiatry2015

Argon blocks the expression of locomotor sensitization to amphetamine through antagonism at the vesicular monoamine transporter-2 and mu-opioid receptor in the nucleus accumbens.

H N David, M Dhilly, M Degoulet, G Poisnel, C Meckler, N Vallée, J-É Blatteau, J-J Risso, M Lemaire, D Debruyne and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

H N David1] Centre de Recherche Hôtel-Dieu de Lévis, CSSS Alphonse-Desjardins, Lévis, QC, Canada [2] Département d'Anesthésiologie, Université Laval, Québec, QC, Canada.
M Dhilly1] ISTCT UMR 6301, CEA DSV/I2BM, LDM-TEP Group, Caen, France [2] ISTCT UMR 6301, CNRS, Caen, France [3] ISTCT UMR 6301, Université de Caen Basse-Normandie, Normandie-Université, Caen, France.
M DegouletFaculté de Médecine, Université de Caen Basse-Normandie, Normandie-Université, Caen, France.
G Poisnel1] ISTCT UMR 6301, CEA DSV/I2BM, LDM-TEP Group, Caen, France [2] ISTCT UMR 6301, CNRS, Caen, France [3] ISTCT UMR 6301, Université de Caen Basse-Normandie, Normandie-Université, Caen, France.
C MecklerInstitut de Recherche Biomédicale des Armées, Toulon, France.
N ValléeInstitut de Recherche Biomédicale des Armées, Toulon, France.
J-É BlatteauInstitut de Recherche Biomédicale des Armées, Toulon, France.
J-J RissoInstitut de Recherche Biomédicale des Armées, Toulon, France.
M LemaireAir Liquide, Centre de Recherche Claude-Delorme, Paris-Saclay, France.
D Debruyne1] ISTCT UMR 6301, CEA DSV/I2BM, LDM-TEP Group, Caen, France [2] ISTCT UMR 6301, CNRS, Caen, France [3] ISTCT UMR 6301, Université de Caen Basse-Normandie, Normandie-Université, Caen, France.
J H Abraini1] Département d'Anesthésiologie, Université Laval, Québec, QC, Canada [2] Faculté de Médecine, Université de Caen Basse-Normandie, Normandie-Université, Caen, France [3] Institut de Recherche Biomédicale des Armées, Toulon, France.
Hôpital d'Instruction des Armées Sainte-Anne · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRNormandie Université · FRAir Liquide (France) · FRCentre intégré de santé et de services sociaux de Chaudière-Appalaches · CACentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the effects of the noble gas argon on the expression of locomotor sensitization to amphetamine and amphetamine-induced changes in dopamine release and mu-opioid neurotransmission in the nucleus accumbens. We found (1) argon blocked the increase in carrier-mediated dopamine release induced by amphetamine in brain slices, but, in contrast, potentiated the decrease in KCl-evoked dopamine release induced by amphetamine, thereby suggesting that argon inhibited the vesicular monoamine transporter-2; (2) argon blocked the expression of locomotor and mu-opioid neurotransmission sensitization induced by repeated amphetamine administration in a short-term model of sensitization in rats; (3) argon decreased the maximal number of binding sites and increased the dissociation constant of mu-receptors in membrane preparations, thereby indicating that argon is a mu-receptor antagonist; (4) argon blocked the expression of locomotor sensitization and context-dependent locomotor activity induced by repeated administration of amphetamine in a long-term model of sensitization. Taken together, these data indicate that argon could be of potential interest for treating drug addiction and dependence.

Indexed as

AmphetamineAnimalsArgonCentral Nervous System SensitizationDopamineLocomotionMaleNucleus AccumbensRatsRats, Sprague-DawleyReceptors, Opioid, muVesicular Monoamine Transport ProteinsAmphetamineArgonDopamineReceptors, Opioid, muSlc18a2 protein, ratVesicular Monoamine Transport Proteins

Identifiers

PMID26151922
PMCPMC5068729
OpenAlexW1490639015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.