ArticleNature communications2015
Voxel-based morphometry predicts shifts in dendritic spine density and morphology with auditory fear conditioning.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 133 citations in OpenAlex.
- Translating the immediate effects of S-Ketamine using hippocampal subfield analysis in healthy subjects-results of a randomized controlled trial.Translational psychiatry · 2021Trial
- The indirect effect of peer problems on adolescent depression through nucleus accumbens volume alteration.Scientific reports · 2020Trial
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- Distinct Physiological Mechanisms Drive Grey Matter Plasticity in Complex Versus Simple Sequence Learning.Human brain mapping · 2026Article
- Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia.JAMA psychiatry · 2026Article
- Distinct Grey Matter Alterations in Untreated Mild to Moderate Chronic Low Back Pain: A Longitudinal Magnetic Resonance Imaging Study.European journal of pain (London, England) · 2026Observational
- Mapping Neurochemical Signatures onto Brain Structure for Neurotransmitter-Informed Discrimination of Schizophrenia Patients from Healthy Controls.medRxiv : the preprint server for health sciences · 2025Article
- Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia.International journal of molecular sciences · 2025Review
- Combination method of macroscopic imaging with MRI and microscopic imaging with super resolution microscopy for brain microstructure analysis.Anatomical science international · 2025Article
- Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides.Neurobiology of stress · 2025Review
- Tracking conditioned fear in pair-housed mice using deep learning and real-time cue delivery.Neurobiology of stress · 2025Article
- MRI textural plasticity in limbic gray matter associated with clinical response to electroconvulsive therapy for psychosis.Molecular psychiatry · 2025Article
- Peripheral DNA Methylation of Cortisol- and Serotonin-Related Genes Predicts Hippocampal Volume in a Pediatric Population.Biological psychiatry global open science · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Intergenerational Effects of Stress - A Focus on Learning and Memory.Current topics in behavioral neurosciences · 2025Review
- Neurogenesis-independent mechanisms of MRI-detectable hippocampal volume increase following electroconvulsive stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Changes in primary visual and auditory cortex of blind and sighted adults following 10 weeks of click-based echolocation training.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Hippocampal volume changes after (R,S)-ketamine administration in patients with major depressive disorder and healthy volunteers.Scientific reports · 2024Article
- Learning to become addicted, one synapse at a time.Neural regeneration research · 2024Article
- Changes in Cortical Microstructure of the Human Brain Resulting from Long-Term Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Neuroimaging has provided compelling data about the brain. Yet the underlying mechanisms of many neuroimaging techniques have not been elucidated. Here we report a voxel-based morphometry (VBM) study of Thy1-YFP mice following auditory fear conditioning complemented by confocal microscopy analysis of cortical thickness, neuronal morphometric features and nuclei size/density. Significant VBM results included the nuclei of the amygdala, the insula and the auditory cortex. There were no significant VBM changes in a control brain area. Focusing on the auditory cortex, confocal analysis showed that fear conditioning led to a significantly increased density of shorter and wider dendritic spines, while there were no spine differences in the control area. Of all the morphology metrics studied, the spine density was the only one to show significant correlation with the VBM signal. These data demonstrate that learning-induced structural changes detected by VBM may be partially explained by increases in dendritic spine density.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.