SynthesisNature communications2015
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
Erratum issuedAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 123 papers, 12 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 12 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- GSTP1 rs1695 Variant and Colorectal Cancer Risk in Women Aged 50+: Insights from Iran's Largest Cohort and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2025Pooled it
- Functional variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are associated with increased risk of colorectal cancer.Human molecular genetics · 2025Pooled it
- Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.Nature genetics · 2022Pooled it
- Large-scale Integrated Analysis of Genetics and Metabolomic Data Reveals Potential Links Between Lipids and Colorectal Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Pooled it
- Pooled it
- Gene-environment interactions and colorectal cancer risk: An umbrella review of systematic reviews and meta-analyses of observational studies.International journal of cancer · 2019Pooled it
- Impact of polymorphisms within genes involved in regulating DNA methylation in patients with metastatic colorectal cancer enrolled in three independent, randomised, open-label clinical trials: a meta-analysis from TRIBE, MAVERICC and FIRE-3.European journal of cancer (Oxford, England : 1990) · 2019Pooled it
- Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.Gastroenterology · 2019Pooled it
- Discovery of common and rare genetic risk variants for colorectal cancer.Nature genetics · 2019Pooled it
- Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.International journal of cancer · 2018Pooled it
- SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population.Oncotarget · 2017Pooled it
- Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer.Journal of the National Cancer Institute · 2015Pooled it
- Article
- SNPWay: streamlined SNP-to-function and pathway over-representation analysis.bioRxiv : the preprint server for biology · 2026Article
- MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle.medRxiv : the preprint server for health sciences · 2026Article
- From SNPs to pathways: a genome-wide benchmark of annotation discrepancies and their impact on protein- and pathway-level inference.BMC genomics · 2026Article
- From SNPs to Pathways: A genome-wide benchmark of annotation discrepancies and their impact on protein- and pathway-level inference.bioRxiv : the preprint server for biology · 2026Article
- A Swedish Haplotype GWAS in Familial and Sporadic Site-Specific Colorectal Cancer.International journal of molecular sciences · 2026Article
- A Multiomic Approach Integrating Genomic and Metabolomic Data Highlights Colorectal Cancer Pathways.Journal of proteome research · 2026Article
- Genetic risk factors modulate the association between physical activity and colorectal cancer.BMC medicine · 2026Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrigendum: genome-wide association study of colorectal cancer identifies six new susceptibility loci.2015 · Kury, Sebastian; Giocannucci, Edward L. and Lemire, Mathiew [Corrected to Küry, Sébastien; Giovannucci, Edward L. and Lemire, Mathieu]
Authors and funding
101 authors.
Fredrick R SchumacherDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Stephanie L SchmitDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Shuo JiaoPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Christopher K EdlundDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Hansong WangEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Ben ZhangDepartment of General Surgery, Third Military Medical University Southwest Hospital, Chongqing 400038, China.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Shu-Chen HuangDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Christopher P FischerUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.
John F HarjuUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.
Gregory E IdosDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Flavio LejbkowiczDepartment of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.
Frank J ManionUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan 48105, USA.ORCID http://orcid.org/0000-0003-1030-6348
Kevin McDonnellDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Caroline E McNeilDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Marilena MelasDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Hedy S RennertDepartment of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34361, Israel.
Wei ShiDepartment of Surgery, Children's Hospital Los Angeles, Los Angeles, California 90027, USA.
Duncan C ThomasDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
David J Van Den BergDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Carolyn M HutterDivision of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20892, USA.
Aaron K AragakiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, California 94612, USA.
Christopher S CarlsonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.
Keith R CurtisPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Charles S FuchsDepartment of Medicine, Brigham and Women's Hospital, Brookline, Massachusetts 02115, USA.
Manish GalaDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Edward L GiovannucciHarvard Medical School, Boston, Massachusetts 02114, USA.
Stephanie M GogartenDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.
Brian HendersonDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Rebecca D JacksonDepartment of Medicine, Ohio State University, Columbus, Ohio 43210, USA.
Laurence N KolonelOffice of Public Health Studies, University of Hawaii Manoa, Honolulu, Hawaii 96822, USA.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Sébastien KüryService de Génétique Médicale, CHU Nantes, Nantes 44093, France.
Andrea LaCroixPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Cecelia A LaurieDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Mathieu LemireOntario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.
David LevineDepartment of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
Jing MaHarvard School of Public Health, Boston, Massachusetts 02114, USA.
Karen W MakarPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Darin TavernaPhoenix College, Phoenix, Arizona 85013, USA.
Cornelia M UlrichPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Kana WuDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Suminori KonoDepartment of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.
Dee W WestCancer Registry of Greater California, Public Health Institute, Sacramento, California 95825, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892-9776, USA.
Stéphane BezieauCentre Hospitalier Universitaire Hotel-Dieu, Nantes, 44093, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
Jenny Chang-ClaudeUnit of Genetic Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
Gerhard A CoetzeeDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
David V ContiDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
David DugganGenetic Basis of Human Disease Division, Translational Genomics Research Institute, Phoenix, Arizona 85004, USA.
Jane C FigueiredoDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Barbara K FortiniDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Steven J GallingerZane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada.
W James GaudermanDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Graham GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Roger GreenDiscipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland A1B 3V6, Canada.
Robert HaileDepartment of Medicine, Division of Oncology, Stanford University, Stanford, California 94305, USA.
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg 69121, Germany.
John L HopperCentre for MEGA Epidemiology, The University of Melbourne, Carlton, Victoria 3010, Australia.
Thomas J HudsonDepartment of Genomics, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada.ORCID http://orcid.org/0000-0002-1376-4849
Eric JacobsEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30329-4251, USA.ORCID http://orcid.org/0000-0002-8458-7659
Motoki IwasakiResearch Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul 120-749, South Korea.
Mark JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria 3010, Australia.
Wei-Hua JiaState Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China.
Amit JoshiDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Li LiDepartment of Family Medicine and Community Health, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Noralene M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, Arizona 85259, USA.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University, Fukuoka 812-8582, Japan.
Victor MorenoCancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL, 08908, Barcelona, Spain.
Bhramar MukherjeeDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
Polly A NewcombCancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
John D PotterCancer Prevention Program, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
Leon RaskinDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Gad RennertDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Stephanie RossePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Gianluca SeveriCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Robert E SchoenDepartment of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA.
Daniela SeminaraEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Xiao-Ou ShuVanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37203-1738, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA.
Shoichiro TsuganeResearch Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Shanghai 2200-25, China.
Brent W ZankeThe University of Ottawa, Ottawa, Ontario K1N 6N5, Canada.
Wei ZhengDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203-1738, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96822, USA.
Graham CaseyDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Stephen B GruberDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98124, USA.
Funding
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MUSC Consortium:Colorectal Cancer Family RegistryU01CA074799 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HAILE, ROBERT WILLIAM · 1997 to 2008
$20.4MUniversity of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4MSEATTLE FAMILIAL COLORECTAL CANCER REGISTRYU01CA074794 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEWCOMB, POLLY A · 1997 to 2007
$14.1MONTARIO REGISTRY FOR STUDIES OF FAMILIAL COLON CANCERU01CA074783 · NCI · CANCER CARE ONTARIO · PI GALLINGER, STEVEN · 1997 to 2008
$12.5MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MGenome-Wide Association Study of Nonsynonymous SNPs in Colon CancerR01CA059045 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 1994 to 2011
$11.5MNCI NIH HHS CA-09-002NCI NIH HHS P01 CA055075NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA140561NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA188392NCI NIH HHS U19 CA148107NCI NIH HHS UM1 CA167551NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NHGRI NIH HHS T32 HG000040NIEHS NIH HHS R01 ES019876NIEHS NIH HHS T32 ES013678NIH HHS S10 OD020069
Abstract
Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P<5.0E-08. These findings provide additional insight into the underlying biological mechanisms of colorectal cancer and demonstrate the scientific value of large consortia-based genetic epidemiology studies.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyCase-Control StudiesColorectal NeoplasmsHumansOdds RatioPolymorphism, Single Nucleotide
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