ArticleeLife2015
Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is criticality a unified setpoint of brain function?Neuron · 2025Pooled it
- Critical neuronal avalanches arise from excitation-inhibition balanced spontaneous activity.iScience · 2026Article
- Irregular and bursty neuronal firing extend spike-timing dependent plasticity window to behavioral timescales.iScience · 2026Article
- Hippocampal criticality tracks cognitive demand and shifts with memory impairment.Communications biology · 2026Article
- Power Laws in Empirical Eigenvalue Spectra.Entropy (Basel, Switzerland) · 2026Article
- Hierarchical whole-brain modeling of critical synchronization dynamics in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Critical scaling of novelty in the cortex.Nature communications · 2026Article
- Cortical state contributions to neuronal response variability in the early visual cortex: A system identification approach.PLoS computational biology · 2025Article
- Interleaving asynchronous and synchronous activity in balanced cortical networks with short term synaptic depression.Nature communications · 2025Article
- The Administration of Ketamine Is Associated with Dose-Dependent Stabilization of Cortical Dynamics in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Self-organized and self-sustained ensemble activity patterns in simulation of mouse primary motor cortex.bioRxiv : the preprint server for biology · 2025Article
- A multi-scale study of thalamic state-dependent responsiveness.PLoS computational biology · 2024Article
- The recovery of parabolic avalanches in spatially subsampled neuronal networks at criticality.Scientific reports · 2024Article
- Existence of multiple transitions of the critical state due to anesthetics.Nature communications · 2024Article
- The recovery of parabolic avalanches in spatially subsampled neuronal networks at criticality.bioRxiv : the preprint server for biology · 2024Article
- Low-dimensional criticality embedded in high-dimensional awake brain dynamics.Science advances · 2024Article
- Article
- Trial-by-trial variability in cortical responses exhibits scaling of spatial correlations predicted from critical dynamics.Cell reports · 2024Article
- Criticality and universality in neuronal cultures during "up" and "down" states.Frontiers in neural circuits · 2024Article
- Multilevel and multifaceted brain response features in spiking, ERP and ERD: experimental observation and simultaneous generation in a neuronal network model with excitation-inhibition balance.Cognitive neurodynamics · 2023Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
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Abstract
Spontaneous fluctuations in neuronal activity emerge at many spatial and temporal scales in cortex. Population measures found these fluctuations to organize as scale-invariant neuronal avalanches, suggesting cortical dynamics to be critical. Macroscopic dynamics, though, depend on physiological states and are ambiguous as to their cellular composition, spatiotemporal origin, and contributions from synaptic input or action potential (AP) output. Here, we study spontaneous firing in pyramidal neurons (PNs) from rat superficial cortical layers in vivo and in vitro using 2-photon imaging. As the animal transitions from the anesthetized to awake state, spontaneous single neuron firing increases in irregularity and assembles into scale-invariant avalanches at the group level. In vitro spike avalanches emerged naturally yet required balanced excitation and inhibition. This demonstrates that neuronal avalanches are linked to the global physiological state of wakefulness and that cortical resting activity organizes as avalanches from firing of local PN groups to global population activity.
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