Evidence map›Paper›PMID 26151580›Full record

ArticleAddictive behaviors2015

Insomnia in alcohol dependent subjects is associated with greater psychosocial problem severity.

Ninad S Chaudhary, Kyle M Kampman, Henry R Kranzler, Michael A Grandner, Swarnalata Debbarma, Subhajit Chakravorty

Abstract read
In one paragraph

Article in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  11. Rethinking trazodone for insomnia in alcohol use disorder.Addiction science & clinical practice · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ninad S ChaudharyPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, United States; Washington University in St. Louis, St. Louis, MO 63110, United States.
Kyle M KampmanPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, United States; Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, United States.
Henry R KranzlerPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, United States; Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, United States.
Michael A GrandnerPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, United States; Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, United States.
Swarnalata DebbarmaPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, United States; Thomas Jefferson University, Philadelphia, PA 19107, United States.
Subhajit ChakravortyPerelman School of Medicine of the University of Pennsylvania, Philadelphia, PA 19104, United States; Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, United States. Electronic address: Subhajit.Chakravorty@uphs.upenn.edu.
Veterans Health Administration · USThomas Jefferson University · USWashington University in St. Louis · US

Funding

Center for the Development of Novel Medications for Cocaine DependenceU54DA039002 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KAMPMAN, KYLE MATTHEW · 2014 to 2018
$5.1M
Quetiapine for the treatment of Type A and Type B alcoholismR01AA016553 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KAMPMAN, KYLE MATTHEW · 2007 to 2011
$2.6M
Novel Approaches to Alcoholism Pharmacotherapy and RiskK24AA013736 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI KRANZLER, HENRY RICHARD · 2002 to 2012
$1.5M
Cardiovascular and Metabolic Risk Factors Associated with Short Sleep DurationK23HL110216 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GRANDNER, MICHAEL A · 2012 to 2016
$813k
Sleep and Health in the Social EnvironmentR21ES022931 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI GRANDNER, MICHAEL A · 2012 to 2013
$436k
The Efficacy of CBT-I in Alcoholics & Its Effects on Remission & RelapseIK2CX000855 · VA · PHILADELPHIA VA MEDICAL CENTER · PI CHAKRAVORTY, SUBHAJIT · 2014 to 2019
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CSRD VA IK2 CX000855NHLBI NIH HHS K23 HL110216NIAAA NIH HHS K24 AA013736NIAAA NIH HHS R01 AA016553NIDA NIH HHS U54 DA039002NIEHS NIH HHS R21 ES022931
6 · The paper itself

Abstract

introductionAlthough psychosocial problems are commonly associated with both alcohol misuse and insomnia, very little is known about the combined effects of insomnia and current alcohol dependence on the severity of psychosocial problems. The present study evaluates whether the co-occurrence of insomnia and alcohol dependence is associated with greater psychosocial problem severity.

methodsAlcohol dependent individuals (N = 123) were evaluated prior to participation in a placebo-controlled medication trial. The Short Index of Problems (SIP), Addiction Severity Index (ASI), Insomnia Severity Index (ISI), and Time Line Follow Back (TLFB), were used to assess psychosocial, employment, and legal problems; insomnia symptoms; and alcohol consumption, respectively. Bivariate and multivariate analyses were used to evaluate the relations between insomnia and psychosocial problems.

resultsSubjects' mean age was 44 years (SD = 10.3), 83% were male, and their SIP sub-scale scores approximated the median for normative data. A quarter of subjects reported no insomnia; 29% reported mild insomnia; and 45% reported moderate-severe insomnia. The insomnia groups did not differ on alcohol consumption measures. The ISI total score was associated with the SIP total scale score (β = 0.23, p = 0.008). Subjects with moderate-severe insomnia had significantly higher scores on the SIP total score, and on the social and impulse control sub-scales, and more ASI employment problems and conflicts with their spouses than others on the ASI.

conclusionIn treatment-seeking alcohol dependent subjects, insomnia may increase alcohol-related adverse psychosocial consequences. Longitudinal studies are needed to clarify the relations between insomnia and psychosocial problems in these subjects.

Indexed as

AdultAlcoholismCross-Sectional StudiesEmploymentFamily ConflictFemaleHumansMaleMental DisordersPennsylvaniaPrevalenceSeverity of Illness IndexSleep Initiation and Maintenance DisordersSocial BehaviorSurveys and QuestionnairesAlcoholismInsomnia and sleep and maintenance disordersPsychosocial factors

Identifiers

PMID26151580
PMCPMC4515378
OpenAlexW840500651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.