ArticleAddictive behaviors2015
New methods shed light on age of onset as a risk factor for nicotine dependence.
Article in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- White matter development and tobacco smoking in young adults: A systematic review with recommendations for future research.Drug and alcohol dependence · 2016Pooled it
- Butt Why? Exploring factors associated with cigarette scavenging behaviors among adult smokers enrolling in a clinical trial for smoking cessation.Addictive behaviors · 2018Trial
- Mental Health and Smoking Cessation: Anxiety and Depression Among Participants in a Public Control Program in Southern Brazil.Journal of lifestyle medicine · 2026Article
- Growing Up with Parents Who Smoke: Genetic and Environmental Effects on Offspring Substance Use and Externalizing Psychopathology From a 20-Year Minnesota Study of Adoptive Families.Behavior genetics · 2026Article
- Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps.Psychiatric genetics · 2026Review
- Neurobiological Mechanisms of Action of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Substance Use Disorders (SUDs)-A Review.Journal of clinical medicine · 2025Review
- Nucleus Accumbens Proteome Disbalance in an Adolescent Mouse Model of Schizophrenia and Nicotine Misuse Comorbidity.Biomedicines · 2025Article
- Age of onset of nicotine use and severity of nicotine addiction symptoms are associated with hippocampal volume in late adolescents and emerging adults.Frontiers in adolescent medicine · 2025Article
- A systematic review on risk factors and reasons for e-cigarette use in adolescents.Tobacco induced diseases · 2025Review
- Nicotine's Effects on Schizophrenia-like Symptoms in a Mice Model: Time Matters.Brain sciences · 2024Article
- Sociodemographic differences in use of nicotine, cannabis, and non-nicotine E-cigarette devices.Drug and alcohol dependence · 2024Article
- Eating Disorder Symptomatology Among Young Adult Cigarette and E-Cigarette Users.Substance use & misuse · 2024Article
- Patient-Level Characteristics Associated with Tobacco Users and Nonusers at a Student-Run Free Clinic.Southern medical journal · 2023Article
- Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice.International journal of molecular sciences · 2023Article
- E-cigarette weight and appetite control beliefs and e-cigarette initiation in young adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2023Article
- Childhood Cigarette Smoking and Risk of Chronic Obstructive Pulmonary Disease in Older U.S. Adults.American journal of respiratory and critical care medicine · 2023Article
- Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood.Pharmacology, biochemistry, and behavior · 2022Review
- Predicting Adolescent Electronic Cigarette Use: Differences by Never, Ever, and Current Users.Journal of pediatric psychology · 2022Article
- Policy Recommendations to Eliminate Tobacco Use and Improve Health from the American Thoracic Society Tobacco Action Committee.Annals of the American Thoracic Society · 2022Article
- Generation 1.5: Years in the United States and Other Factors Affecting Smoking Behaviors Among Asian Americans.Ethnicity & disease · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionEarly onset of substance use is a risk factor for later drug use, abuse, and dependence. This study examines how the rate of nicotine dependence differs as a function of age of onset of regular smoking in continuous time, in order to identify critical age periods that are most predictive of later dependence for males and females.
methodsTime-varying effect modeling (TVEM) can reveal specific ages of onset that confer greatest risk for adult nicotine dependence. The rate of dependence in adulthood is modeled as a flexible function of age of onset using a subset of adults (N = 15,748) from the National Epidemiologic Survey on Alcohol and Related Conditions who ever smoked regularly.
resultsThe peak risk of adult nicotine dependence coincides with onset of regular use at approximately 10 years old, with an elevated risk persisting to 20 years. The risk of dependence is significantly higher for females compared to males for onset of regular use between ages 9 and 18.
conclusionsResults suggest that the risk of adult nicotine dependence is highest when onset of regular smoking occurs at around 10 years, though the associated risk is high for ages of onset into young adulthood. Early onset of regular use is a relatively stronger risk factor for adolescent females than males. Smoking prevention programs should focus on late childhood through early adolescence, particularly among females. TVEM provides a more nuanced understanding of the risk associated with different ages of onset of health risk behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.