Evidence map›Paper›PMID 26151496›Full record

ArticleNature communications2015

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Pei-Lung Chen, Shyang-Rong Shih, Pei-Wen Wang, Ying-Chao Lin, Chen-Chung Chu, Jung-Hsin Lin, Szu-Chi Chen, Ching-Chung Chang, Tien-Shang Huang, Keh Sung Tsai and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  8. World journal of gastroenterology · 2025
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  10. Review
  11. Article
  12. Article
  13. The genetics of Graves' disease.Reviews in endocrine & metabolic disorders · 2024
    Review
  14. Biomedicines · 2023
    Article
  15. Article
  16. Review
  17. Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report and literature review.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022
    Article
  18. Article
  19. Progress in study on the association between HLA genetic variation and adverse drug reactions.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Pei-Lung Chen1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Medical Genetics, National Taiwan University Hospital, Taipei 100, Taiwan. [3] Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei 100, Taiwan. [4] Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan. [5] Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 106, Taiwan.
Shyang-Rong Shih1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Pei-Wen WangDepartment of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Ying-Chao LinInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Chen-Chung ChuImmunogenetics Laboratory, Department of Medical Research, Mackay Memorial Hospital, Taipei 251, Taiwan.
Jung-Hsin Lin1] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan. [2] School of Pharmacy, National Taiwan University, Taipei 100, Taiwan. [3] Research Center for Applied Sciences, Academia Sinica, Taipei 833, Taiwan.
Szu-Chi Chen1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Internal Medicine, New Taipei City Hospital, New Taipei 220, Taiwan.
Ching-Chung Chang1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan. [3] Department of Internal Medicine, China Medical University, Taichung 404, Taiwan.
Tien-Shang Huang1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan. [3] Department of Social Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan. [4] Department of Internal Medicine, Cathay General Hospital, Taipei 106, Taiwan.
Keh Sung Tsai1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [3] Department of Laboratory Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Fen-Yu TsengDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Chih-Yuan WangDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Jin-Ying LuDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Wei-Yih ChiuDivision of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Chien-Ching ChangInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Yu-Hsuan ChenSchool of Pharmacy, National Taiwan University, Taipei 100, Taiwan.
Yuan-Tsong Chen1] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan. [2] Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27708, USA.
Cathy Shen-Jang FannInstitute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.
Wei-Shiung Yang1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei 100, Taiwan. [3] Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan. [4] Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei 106, Taiwan. [5] Department of Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Tien-Chun Chang1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
National Taiwan University Hospital · TWInstitute of Biomedical Sciences, Academia Sinica · TWNational Taiwan University · TWChina Medical University · TWKaohsiung Chang Gung Memorial Hospital · TWMackay Memorial Hospital · TWResearch Center for Applied Science, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graves' disease is the leading cause of hyperthyroidism affecting 1.0-1.6% of the population. Antithyroid drugs are the treatment cornerstone, but may cause life-threatening agranulocytosis. Here we conduct a two-stage association study on two separate subject sets (in total 42 agranulocytosis cases and 1,208 Graves' disease controls), using direct human leukocyte antigen genotyping and SNP-based genome-wide association study. We demonstrate HLA-B*38:02 (Armitage trend Pcombined=6.75 × 10(-32)) and HLA-DRB1*08:03 (Pcombined=1.83 × 10(-9)) as independent susceptibility loci. The genome-wide association study identifies the same signals. Estimated odds ratios for these two loci comparing effective allele carriers to non-carriers are 21.48 (95% confidence interval=11.13-41.48) and 6.13 (95% confidence interval=3.28-11.46), respectively. Carrying both HLA-B*38:02 and HLA-DRB1*08:03 increases odds ratio to 48.41 (Pcombined=3.32 × 10(-21), 95% confidence interval=21.66-108.22). Our results could be useful for antithyroid-induced agranulocytosis and potentially for agranulocytosis caused by other chemicals.

Indexed as

Genetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHLA AntigensAgranulocytosisAntithyroid AgentsHLA-B AntigensHLA-DRB1 ChainsHumansOdds RatioAntithyroid AgentsHLA AntigensHLA-B AntigensHLA-DRB1 Chains

Identifiers

PMID26151496
PMCPMC4506516
OpenAlexW931662247

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.