ArticleInternational journal of molecular medicine2015
Pathogenesis of glucocorticoid-induced avascular necrosis: A microarray analysis of gene expression in vitro.
Article in International journal of molecular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Pravastatin combined with fibrin sealant-embedded BMSCs enhances recovery in steroid-induced avascular necrosis of the femoral head.Scientific reports · 2026Article
- MicroRNA Expression Profile in the Patient's Plasma Exosomes of Alcohol-Induced Osteonecrosis of Femoral Head: Potential Vascular Regulation Mechanism.Journal of cellular and molecular medicine · 2025Article
- The protective role of vitamins C and E in steroid-induced femoral head osteonecrosis: An experimental study in rats.Joint diseases and related surgery · 2024Article
- The effects of thymoquinone on steroid-induced femoral head osteonecrosis: An experimental study in rats.Joint diseases and related surgery · 2022Article
- Therapeutic perspectives of exosomes in glucocorticoid-induced osteoarthrosis.Frontiers in surgery · 2022Review
- Knockdown of long non-coding RNA HOTAIR promotes bone marrow mesenchymal stem cell differentiation by sponging microRNA miR-378g that inhibits nicotinamide N-methyltransferase.Bioengineered · 2021Article
- Non-coding RNA Identification in Osteonecrosis of the Femoral Head Using Competitive Endogenous RNA Network Analysis.Orthopaedic surgery · 2021Article
- Influence of MicroRNA-141 on Inhibition of the Proliferation of Bone Marrow Mesenchymal Stem Cells in Steroid-Induced Osteonecrosis via SOX11.Orthopaedic surgery · 2020Article
- Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.Disease markers · 2019Article
- Noncoding RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.BioMed research international · 2019Review
- Article
- Different changes of microarchitectures of cortical and cancellous bones in sheep femoral head after long-term glucocorticoid interventions.Scientific reports · 2018Article
- MicroRNA-mediated interacting circuits predict hypoxia and inhibited osteogenesis of stem cells, and dysregulated angiogenesis are involved in osteonecrosis of the femoral head.International orthopaedics · 2018Article
- Emerging roles of MicroRNAs in osteonecrosis of the femoral head.Cell proliferation · 2018Review
- miR-10a-5p, miR-99a-5p and miR-21-5p are steroid-responsive circulating microRNAs.American journal of translational research · 2018Article
- Efficiency of Cell Therapy to GC-Induced ONFH: BMSCs with Dkk-1 Interference Is Not Superior to Unmodified BMSCs.Stem cells international · 2018Article
- Microarray‑based screening of differentially expressed genes in glucocorticoid‑induced avascular necrosis.Molecular medicine reports · 2017Article
- The impact of high total cholesterol and high low-density lipoprotein on avascular necrosis of the femoral head in low-energy femoral neck fractures.Journal of orthopaedic surgery and research · 2017Article
- MiR-708 promotes steroid-induced osteonecrosis of femoral head, suppresses osteogenic differentiation by targeting SMAD3.Scientific reports · 2016Article
- Effects of osteoprotegerin, RANK and RANKL on bone destruction and collapse in avascular necrosis femoral head.American journal of translational research · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Avascular necrosis of the femoral head (ANFH) occurs following exposure to corticosteroids, and the proliferative capacity of the mesenchymal stem cells (MSCs) belonging to ANFH was reduced. The previous studies indicate that microRNA (miRNA) has an important regulatory role during proliferation and osteogenic differentiation of MSCs. Therefore, MSCs were obtained from healthy adults, and were cultured and osteogenically‑induced by different dexamethasone concentrations. The proliferation and osteogenic differentiation capacities were examined through observing cellular morphology, alkaline phosphatase and alizarin red; miRNA expression was investigated using an miRNA gene chip and miRNA of differential expressions were retrieved through a database to analyze its regulatory effect. Dexamethasone at a concentration of 10(‑7) mol/l induced the proliferation and osteogenic differentiation of MSCs and resulted in evident miRNA expression profile changes. In total, 11 miRNAs were upregulated at 10(‑7) mol/l while 6 were downregulated, and partial miRNA was identified to participate in the regulation of cell proliferation and cell apoptosis, MSC osteogenic differentiation, lipid metabolism and other processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.