Evidence map›Paper›PMID 26151059›Full record

ReviewHepatobiliary surgery and nutrition2015

Detectability and clinical significance of serum hepatitis B virus ribonucleic acid.

Yi-Wen Huang, Kazuaki Chayama, Jia-Horng Kao, Sien-Sing Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hepatobiliary surgery and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yi-Wen Huang1 Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan ; 2 School of Medicine, Taipei Medical University, Taipei, Taiwan ; 3 Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 4 Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, 5 Liver Research Project Center, Hiroshima University, Hiroshima, Japan ; 6 Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 7 School of Medicine, Fu-Jen Catholic University College of Medicine, Taipei, Taiwan.
Kazuaki Chayama1 Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan ; 2 School of Medicine, Taipei Medical University, Taipei, Taiwan ; 3 Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 4 Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, 5 Liver Research Project Center, Hiroshima University, Hiroshima, Japan ; 6 Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 7 School of Medicine, Fu-Jen Catholic University College of Medicine, Taipei, Taiwan.
Jia-Horng Kao1 Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan ; 2 School of Medicine, Taipei Medical University, Taipei, Taiwan ; 3 Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 4 Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, 5 Liver Research Project Center, Hiroshima University, Hiroshima, Japan ; 6 Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 7 School of Medicine, Fu-Jen Catholic University College of Medicine, Taipei, Taiwan.
Sien-Sing Yang1 Liver Center, Cathay General Hospital Medical Center, Taipei, Taiwan ; 2 School of Medicine, Taipei Medical University, Taipei, Taiwan ; 3 Division of Gastroenterology, Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 4 Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical & Health Science, 5 Liver Research Project Center, Hiroshima University, Hiroshima, Japan ; 6 Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan ; 7 School of Medicine, Fu-Jen Catholic University College of Medicine, Taipei, Taiwan.
Taipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum hepatitis B virus (HBV) RNA is detected during treatment with nucleoside analogue as a consequence of interrupted reverse transcription (RT) and unaffected replicative intermediates. The presence of serum HBV RNA in chronic HBV patients is confirmed by using ribonuclease digestion. Serum HBV RNA is differentially inhibited by interferon, but not by nucleoside analogue. The inhibitory effect of interferon on HBV RNA replicative intermediates may potentiate the suppression of HBV replication. Clinical significance of serum HBV RNA includes: (I) reflect the antiviral potency of nucleoside analogue; (II) predictor of early emergence of viral mutation during lamivudine therapy; (III) independently predict initial virologic response or earlier HBV suppression during nucleoside analogue therapy; (IV) predict HBV reactivation after discontinuation of nucleoside analogue. Thus, serum HBV RNA might be useful to optimize treatment efficacy in patients with chronic HBV, including shifting of oral antivirals or conversion to immunomodulatory agent i.e., interferon. Furthermore, serum HBV RNA levels correlate better with serum quantitative HBsAg (qHBsAg) than with serum HBV DNA levels. The predictive role of serum HBV RNA in long-term treatment effects of nucleoside analogue needs further study.

Indexed as

interferonNucleoside analoguereplicative intermediates

Identifiers

PMID26151059
PMCPMC4465601
OpenAlexW1003739988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.