Evidence map›Paper›PMID 26151056›Full record

ReviewHepatobiliary surgery and nutrition2015

Carotenoids and non-alcoholic fatty liver disease.

Bahiddin Yilmaz, Kazim Sahin, Hande Bilen, Ibrahim H Bahcecioglu, Birdal Bilir, Sara Ashraf, Karim J Halazun, Omer Kucuk

Abstract readReview
In one paragraph

Review in Hepatobiliary surgery and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Effects ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Article
  5. Article
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  8. Article
  9. Review
  10. Article
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  12. Article
  13. Review
  14. Review
  15. Article
  16. Targeting hepatic macrophages for non-alcoholic fatty liver disease therapy.Frontiers in cell and developmental biology · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Bahiddin Yilmaz1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Kazim Sahin1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Hande Bilen1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Ibrahim H Bahcecioglu1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Birdal Bilir1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Sara Ashraf1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Karim J Halazun1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Omer Kucuk1 Winship Cancer Institute, Emory University, Atlanta, GA, USA ; 2 Division of Animal Nutrition, Faculty of Veterinary Medicine, 3 Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey ; 4 Department of Surgery, Emory University, Atlanta, GA, USA.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a growing health problem around the world, especially in developed countries. NAFLD includes all cases of fatty liver disease from simple steatosis to cirrhosis, without excessive alcohol intake, use of steatogenic medication or hereditary disorders. Pathogenesis is associated with dietary high fat intake, decreased free fatty acid (FFA) oxidation, increased hepatic lipogenesis and lipolysis from the adipose tissue. These metabolic alterations contribute to the hepatic fat accumulation. Consequently, stimulated oxidative stress and inflammation play a major role in hepatocellular damage. Therefore, antioxidant and anti-inflammatory agents may have a role in the prevention of this disease. Carotenoids are potent antioxidant and anti-inflammatory micronutrients, which have been investigated in the prevention and treatment of NAFLD. The main sources of the carotenoids are fruits and vegetables. In this article we review the potential role and possible molecular mechanism of carotenoids in NAFLD.

Indexed as

antioxidantcarotenoidFatty livernon-alcoholic steatohepatitisoxidative stresssteatosis

Identifiers

PMID26151056
PMCPMC4465602
OpenAlexW1483344588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.