ReviewJournal of traditional and complementary medicine2015
Crocus sativus L. (saffron) for cancer chemoprevention: A mini review.
Review in Journal of traditional and complementary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06464380 (Anti Cancer Potential of Saffron in Hepatocellular Carcinoma), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anti Cancer Potential of Saffron in Hepatocellular Carcinoma
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Pooled it
- In vitro effects of crocin on the possible anticancer properties of Lactococcus lactis against colorectal adenocarcinoma cells.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Water-soluble carotenoid: focused on natural carotenoid crocin.Food science and biotechnology · 2025Review
- Functional Feed for Laying Hens: Application of Saffron Extract as Eco-Friendly Supplement With Cholesterol-Lowering Properties.Veterinary medicine and science · 2025Article
- Optimization of Extraction and Purification of Flavonoids from Stigmaless Floral Residues ofMolecules (Basel, Switzerland) · 2024Article
- Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities.Plants (Basel, Switzerland) · 2024Review
- Climate change and the sustainable use of medicinal plants: a call for "new" research strategies.Frontiers in pharmacology · 2024Article
- The Combined Effect of Curcumin and Crocin on the Reduction of Inflammatory Responses in Arthritic Rats.Current medicinal chemistry · 2024Article
- Identification of the therapeutic mechanism of the saffron crocus on glioma through network pharmacology and bioinformatics analysis.Medical oncology (Northwood, London, England) · 2023Article
- Network pharmacology and experimental verification reveal the mechanism of safranal against glioblastoma (GBM).Frontiers in oncology · 2023Article
- Current Knowledge of the Antidepressant Activity of Chemical Compounds fromPharmaceuticals (Basel, Switzerland) · 2022Review
- Decoding cancer and herbal renaissance.Longhua Chinese medicine · 2022Article
- Nano reduction coupled with encapsulation as a novel technique for utilising millet proteins as future foods.Ultrasonics sonochemistry · 2022Article
- Potential Role of Phytochemical Extract from Saffron in Development of Functional Foods and Protection of Brain-Related Disorders.Oxidative medicine and cellular longevity · 2022Review
- Untargeted Metabolomics Analysis ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Bio-guided bioactive profiling and HPLC-DAD fingerprinting of Ukrainian saffron (Crocus sativus stigmas): moving from correlation toward causation.BMC complementary medicine and therapies · 2021Article
- Saffron: A potential drug-supplement for severe acute respiratory syndrome coronavirus (COVID) management.Heliyon · 2021Review
- Safranal Inhibits AngiogenesisFrontiers in oncology · 2021Article
- Potential Nutraceutical Benefits of In Vivo Grown Saffron (Crocus sativus L.) As Analgesic, Anti-inflammatory, Anticoagulant, and Antidepressant in Mice.Plants (Basel, Switzerland) · 2020Article
- Salycilic Acid Induces Exudation of Crocin and Phenolics in Saffron Suspension-Cultured Cells.Plants (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is one of the most feared diseases globally and there has been a sustained rise in its incidence in both developing and developed countries. Despite the growing therapeutic options for patients with cancer, their efficacy is time-limited and non-curative. Hence to overcome these drawbacks, an incessant screening for superior and safer drugs has been ongoing for numerous decades, resulting in the detection of anti-cancer properties of several phytochemicals. Chemoprevention using readily available natural substances from vegetables, fruits, herbs and spices is one of the significantly important approaches for cancer prevention in the present era. Among the spices, Crocus sativus L. (saffron; fān hóng huā) has generated interest because pharmacological experiments have established numerous beneficial properties including radical scavenging, anti-mutagenic and immuno-modulating effects. The more powerful components of saffron are crocin, crocetin and safranal. Studies in animal models and with cultured human malignant cell lines have demonstrated antitumor and cancer preventive activities of saffron and its main ingredients. This review provides a brief insight into the anticancer properties of saffron and its components.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.