ArticleFrontiers in genetics2015
DNA/RNA transverse current sequencing: intrinsic structural noise from neighboring bases.
Article in Frontiers in genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Nanopore sequencing for smear-negative pulmonary tuberculosis-a multicentre prospective study in China.Annals of clinical microbiology and antimicrobials · 2024Article
- Diagnostic value of a nanopore sequencing assay of bronchoalveolar lavage fluid in pulmonary tuberculosis.BMC pulmonary medicine · 2023Article
- Rapid Diagnosis ofFrontiers in medicine · 2022Article
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- Genomic big data hitting the storage bottleneck.EMBnet.journal · 2018Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Nanopore DNA sequencing via transverse current has emerged as a promising candidate for third-generation sequencing technology. It produces long read lengths which could alleviate problems with assembly errors inherent in current technologies. However, the high error rates of nanopore sequencing have to be addressed. A very important source of the error is the intrinsic noise in the current arising from carrier dispersion along the chain of the molecule, i.e., from the influence of neighboring bases. In this work we perform calculations of the transverse current within an effective multi-orbital tight-binding model derived from first-principles calculations of the DNA/RNA molecules, to study the effect of this structural noise on the error rates in DNA/RNA sequencing via transverse current in nanopores. We demonstrate that a statistical technique, utilizing not only the currents through the nucleotides but also the correlations in the currents, can in principle reduce the error rate below any desired precision.
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