ArticleFrontiers in plant science2015
An Arabidopsis neutral ceramidase mutant ncer1 accumulates hydroxyceramides and is sensitive to oxidative stress.
Article in Frontiers in plant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Unraveling the impact of abiotic stress on conserved microRNA expression and their target genes inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- The Transcriptional Responses of Ectomycorrhizal Fungus,Journal of fungi (Basel, Switzerland) · 2022Article
- Proteomic Analysis Revealed Different Molecular Mechanisms of Response to PEG Stress in Drought-Sensitive and Drought-Resistant Sorghums.International journal of molecular sciences · 2022Article
- Sphingolipids at Plasmodesmata: Structural Components and Functional Modulators.International journal of molecular sciences · 2022Review
- Diversity in sphingolipid metabolism across land plants.Journal of experimental botany · 2022Review
- Study of natural diversity in response to a key pathogenicity regulator of Ralstonia solanacearum reveals new susceptibility genes in Arabidopsis thaliana.Molecular plant pathology · 2022Article
- The Two Classes of Ceramide Synthases Play Different Roles in Plant Immunity and Cell Death.Frontiers in plant science · 2022Article
- Jasmonates modulate sphingolipid metabolism and accelerate cell death in the ceramide kinase mutant acd5.Plant physiology · 2021Article
- Sphingolipid metabolism, transport, and functions in plants: Recent progress and future perspectives.Plant communications · 2021Review
- Early Transcriptome Response ofFrontiers in fungal biology · 2021Article
- Decreased R:FR Ratio in Incident White Light Affects the Composition of Barley Leaf Lipidome and Freezing Tolerance in a Temperature-Dependent Manner.International journal of molecular sciences · 2020Article
- A potential pathway for flippase-facilitated glucosylceramide catabolism in plants.Plant signaling & behavior · 2020Article
- Phloem Exudate Protein Profiles during Drought and Recovery Reveal Abiotic Stress Responses in Tomato Vasculature.International journal of molecular sciences · 2020Article
- Sphingolipids: towards an integrated view of metabolism during the plant stress response.The New phytologist · 2020Review
- Review
- A neutral ceramidase, NlnCDase, is involved in the stress responses of brown planthopper, Nilaparvata lugens (Stål).Scientific reports · 2018Article
- Sphingolipid Distribution, Content and Gene Expression during Olive-Fruit Development and Ripening.Frontiers in plant science · 2018Article
- Orosomucoid Proteins Interact with the Small Subunit of Serine Palmitoyltransferase and Contribute to Sphingolipid Homeostasis and Stress Responses in Arabidopsis.The Plant cell · 2016Article
- Plant sphingolipids: Their importance in cellular organization and adaption.Biochimica et biophysica acta · 2016Review
- Identification and Characterization of Salvia miltiorrhizain miRNAs in Response to Replanting Disease.PloS one · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ceramidases hydrolyze ceramide into sphingosine and fatty acids and, although ceramidases function as key regulators of sphingolipid homeostasis in mammals, their roles in plants remain largely unknown. Here, we characterized the Arabidopsis thaliana ceramidase AtNCER1, a homolog of human neutral ceramidase. AtNCER1 localizes predominantly on the endoplasmic reticulum. The ncer1 T-DNA insertion mutants had no visible phenotype, but accumulated hydroxyceramides, and showed increased sensitivity to oxidative stress induced by methyl viologen. Plants over-expressing AtNCER1 showed increased tolerance to oxidative stress. These data indicate that the Arabidopsis neutral ceramidase affects sphingolipid homeostasis and oxidative stress responses.
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