ArticleFrontiers in neuroscience2015
Case study: auditory brain responses in a minimally verbal child with autism and cerebral palsy.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Neurobiology of language in autism: a systematic review of pediatric studies.Brain imaging and behavior · 2026Pooled it
- Toward an Individualized Neural Assessment of Receptive Language in Children.Journal of speech, language, and hearing research : JSLHR · 2020Article
- Mobile EEG in research on neurodevelopmental disorders: Opportunities and challenges.Developmental cognitive neuroscience · 2019Review
- An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children.Journal of visualized experiments : JoVE · 2018Article
- Distinct ERP profiles for auditory processing in infants at-risk for autism and language impairment.Scientific reports · 2018Article
- Annual Research Review: Understudied populations within the autism spectrum - current trends and future directions in neuroimaging research.Journal of child psychology and psychiatry, and allied disciplines · 2017Review
- Neurogaming Technology Meets Neuroscience Education: A Cost-Effective, Scalable, and Highly Portable Undergraduate Teaching Laboratory for Neuroscience.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2017Article
- Implications of Oxytocin in Human Linguistic Cognition: From Genome to Phenome.Frontiers in neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An estimated 30% of individuals with autism spectrum disorders (ASD) remain minimally verbal into late childhood, but research on cognition and brain function in ASD focuses almost exclusively on those with good or only moderately impaired language. Here we present a case study investigating auditory processing of GM, a nonverbal child with ASD and cerebral palsy. At the age of 8 years, GM was tested using magnetoencephalography (MEG) whilst passively listening to speech sounds and complex tones. Where typically developing children and verbal autistic children all demonstrated similar brain responses to speech and nonspeech sounds, GM produced much stronger responses to nonspeech than speech, particularly in the 65-165 ms (M50/M100) time window post-stimulus onset. GM was retested aged 10 years using electroencephalography (EEG) whilst passively listening to pure tone stimuli. Consistent with her MEG response to complex tones, GM showed an unusually early and strong response to pure tones in her EEG responses. The consistency of the MEG and EEG data in this single case study demonstrate both the potential and the feasibility of these methods in the study of minimally verbal children with ASD. Further research is required to determine whether GM's atypical auditory responses are characteristic of other minimally verbal children with ASD or of other individuals with cerebral palsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.