Evidence map›Paper›PMID 26150718›Full record

ArticleInternational journal of nanomedicine2015

Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer.

Yanrong Cai, Lieping Guo, Hongxing Shen, Xiaofei An, Hong Jiang, Fang Ji, Yunfei Niu

RetractedAbstract readRetracted Publication
In one paragraph

Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. [Research progress on mesoporous bioactive glass].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2018
    Review
  10. Article
  11. Applications of Metals for Bone Regeneration.International journal of molecular sciences · 2018
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yanrong CaiThe College of Basic Science of Medicine, Hunan University of Traditional Chinese Medicine, Changsha, People's Republic of China.
Lieping GuoDepartment of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Hongxing ShenDepartment of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Xiaofei AnDepartment of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Hong JiangSchool of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, People's Republic of China.
Fang JiDepartment of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.
Yunfei NiuDepartment of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b-PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b-PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b-PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.

Indexed as

Biocompatible Materials3T3 CellsAnimalsCell ProliferationCeramicsLithiumMiceOsteogenesisPolyestersPolyethylene GlycolsPolylysineTissue ScaffoldsBiocompatible MaterialsBioglassLithiummonomethoxy (polyethylene glycol)-poly(lactide-co-glycolide)-poly(lysine)PolyestersPolyethylene GlycolsPolylysinebioactivitybone repaircell proliferationcopolymerdegradabilityMBGosteogenesis

Identifiers

PMID26150718
PMCPMC4484672

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.