ArticleOccupational and environmental medicine2015
Organophosphate insecticide use and cancer incidence among spouses of pesticide applicators in the Agricultural Health Study.
Article in Occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
82 citing papers in PubMed, 4 syntheses or guidelines pooled it, 253 citations in OpenAlex.
- Allium cepa test vs. insecticides: a scientometric and meta-analytical review.Environmental science and pollution research international · 2022Pooled it
- Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Association between pesticide exposure and colorectal cancer risk and incidence: A systematic review.Ecotoxicology and environmental safety · 2021Pooled it
- Environmental exposures and breast cancer risk in the context of underlying susceptibility: A systematic review of the epidemiological literature.Environmental research · 2020Pooled it
- Endocrine-Disrupting Pesticides as Drivers of Human Disease: Mechanistic Toxicology and Life-Course Health Effects.International journal of molecular sciences · 2026Review
- Chlorpyrifos and Chlorpyrifos-Oxon: A Widening Spectrum of Toxicity.International journal of molecular sciences · 2026Review
- Residential proximity to Superfund sites and breast cancer incidence in a nationwide cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Multifaceted mechanisms by which environmental endocrine-disrupting chemicals promote cancer progression: crosstalk among carcinogenesis, immunity, and metabolic reprogramming: narrative mini-review.Frontiers in molecular biosciences · 2026Review
- Global Evidence on Monitoring Human Pesticide Exposure.Journal of xenobiotics · 2025Review
- Phthalates unleashed: decoding ovarian carcinogenesis through multi-omics networks, single-cell insights, and molecular docking.Journal of ovarian research · 2025Article
- Nitrate and disinfection by-products in drinking water and risk of ovarian cancer.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- An Integrated Nanosensor/Smartphone Platform for Point-of-Care Biomonitoring of Human Exposure to Pesticides.Analytical chemistry · 2025Article
- Sustainable diets and cancer: a systematic review and meta-analysis.EClinicalMedicine · 2025Article
- Recent perspectives on biotechnological production, modulation and applications of glycerophosphoryl diester phosphodiesterases.Biodegradation · 2025Review
- LC-MS/MS-Profiling of Human Serum Unveils Significant Increase in Neuroinflammation and Carcinogenesis Following Chronic Organophosphate Exposure.Journal of proteome research · 2025Article
- Article
- Kinetic analysis suggests that malathion at low environmental exposures is not toxic to humans.PloS one · 2025Article
- Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?Antioxidants (Basel, Switzerland) · 2024Review
- Association of ambient air pollution and pesticide mixtures on respiratory inflammatory markers in agricultural communities.Environmental research, health : ERH · 2024Article
- Impact of glyphosate-based herbicide exposure through maternal milk on offspring's antioxidant status, neurodevelopment, and behavior.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
objectivesOrganophosphates (OPs) are among the most commonly used insecticides. OPs have been linked to cancer risk in some epidemiological studies, which have been largely conducted in predominantly male populations. We evaluated personal use of specific OPs and cancer incidence among female spouses of pesticide applicators in the prospective Agricultural Health Study cohort.
methodsAt enrolment (1993-1997), spouses provided information about ever use of specific pesticides, including 10 OPs, demographic information, reproductive health history and other potential confounders. We used Poisson regression to estimate relative risks (RRs) and 95% CIs for all cancers diagnosed through 2010 for North Carolina and through 2011 for Iowa.
resultsAmong 30,003 women, 25.9% reported OP use, and 718 OP-exposed women were diagnosed with cancer during the follow-up period. Any OP use was associated with an elevated risk of breast cancer (RR=1.20, 95% CI 1.01 to 1.43). Malathion, the most commonly reported OP, was associated with increased risk of thyroid cancer (RR=2.04, 95% CI 1.14 to 3.63) and decreased risk of non-Hodgkin lymphoma (RR=0.64, 95% CI 0.41 to 0.99). Diazinon use was associated with ovarian cancer (RR=1.87, 95% CI 1.02 to 3.43).
conclusionsWe observed increased risk with OP use for several hormonally-related cancers, including breast, thyroid and ovary, suggesting potential for hormonally-mediated effects. This study represents the first comprehensive analysis of OP use and cancer risk among women, and thus demonstrates a need for further evaluation.
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