ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
From within-host interactions to epidemiological competition: a general model for multiple infections.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Conditions for invasion and persistence of a satellite that does not affect the replication and virulence of its helper virus.Virus evolution · 2026Article
- Responses to pathogen exposure in sentinel juvenile fall-run Chinook salmon in the Sacramento River, CA.Conservation physiology · 2023Article
- Ecological and evolutionary dynamics of multi-strain RNA viruses.Nature ecology & evolution · 2022Review
- Sequential infection ofParasitology · 2021Article
- The Epidemiology of Plant Virus Disease: Towards a New Synthesis.Plants (Basel, Switzerland) · 2020Review
- Interplay between competitive and cooperative interactions in a three-player pathogen system.Royal Society open science · 2020Article
- Linking community assembly and structure across scales in a wild mouse parasite community.Ecology and evolution · 2019Article
- Article
- Bacterial microbiota composition ofPeerJ · 2019Article
- The effect of the infection within the individual host on its propagation in the population.Infectious Disease Modelling · 2018Article
- Invasions of Host-Associated Microbiome Networks.Advances in ecological research · 2017Article
- Within-host dynamics of infection: from ecological insights to evolutionary predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Within-host competitive interactions as a mechanism for the maintenance of parasite diversity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many hosts are infected by several parasite genotypes at a time. In these co-infected hosts, parasites can interact in various ways thus creating diverse within-host dynamics, making it difficult to predict the expression and the evolution of virulence. Moreover, multiple infections generate a combinatorial diversity of cotransmission routes at the host population level, which complicates the epidemiology and may lead to non-trivial outcomes. We introduce a new model for multiple infections, which allows any number of parasite genotypes to infect hosts and potentially coexist in the population. In our model, parasites affect one another's within-host growth through density-dependent interactions and by means of public goods and spite. These within-host interactions determine virulence, recovery and transmission rates, which are then integrated in a transmission network. We use analytical solutions and numerical simulations to investigate epidemiological feedbacks in host populations infected by several parasite genotypes. Finally, we discuss general perspectives on multiple infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.