ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Crossing the scale from within-host infection dynamics to between-host transmission fitness: a discussion of current assumptions and knowledge.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed.
- From infection to cholangiocarcinoma: Why opisthorchiids break these rules.One health (Amsterdam, Netherlands) · 2026Review
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- Longitudinal Impacts of Forest Loss on Bartonella and Hemotropic Mycoplasma Dynamics in Vampire Bats Within a Fragmented Habitat.Molecular ecology · 2026Article
- Data aggregation and mechanistic modeling enable dose-response analysis of SARS-CoV-1 in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- From Trait-Structured Within-Host Dynamics to SIR Models: A Multiscale Framework With Re-Exposure.Bulletin of mathematical biology · 2026Article
- Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission.PLoS pathogens · 2026Article
- Should public health policy exempt cases with low viral load from isolation during an epidemic?: a modelling study.Infectious Disease Modelling · 2025Article
- Linking within-host immune dynamics to between-host transmission and reinfection risk.Journal of theoretical biology · 2025Article
- A fundamental limit to the effectiveness of traveller screening with molecular tests.Epidemiology and infection · 2025Article
- Emergence of Dengue Virus Serotypes 1 and 3 in Mahottari and Adjacent Areas of Southern Nepal.Pathogens (Basel, Switzerland) · 2025Article
- Variability in infection dynamics emerges from the interplay between unique host and pathogen characteristics.Scientific reports · 2025Article
- Review
- Scaling up to understand disease risk: distinct roles of host functional traits in shaping infection risk of avian malaria across different scales.Proceedings. Biological sciences · 2025Article
- Public Health Impact of Paxlovid as Treatment for COVID-19, United States.Emerging infectious diseases · 2024Article
- Quantifying the relationship between within-host dynamics and transmission for viral diseases of livestock.Journal of the Royal Society, Interface · 2024Article
- Within- and between-host dynamics of producer and non-producer pathogens.Parasitology · 2023Article
- Simplified within-host and Dose-response Models of SARS-CoV-2.Journal of theoretical biology · 2023Article
- Interspecific host competition and parasite virulence evolution.Biology letters · 2023Article
- Correlation of viral loads in disease transmission could affect early estimates of the reproduction number.Journal of the Royal Society, Interface · 2023Article
- An agent-based nested model integrating within-host and between-host mechanisms to predict an epidemic.PloS one · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The progression of an infection within a host determines the ability of a pathogen to transmit to new hosts and to maintain itself in the population. While the general connection between the infection dynamics within a host and the population-level transmission dynamics of pathogens is widely acknowledged, a comprehensive and quantitative understanding that would allow full integration of the two scales is still lacking. Here, we provide a brief discussion of both models and data that have attempted to provide quantitative mappings from within-host infection dynamics to transmission fitness. We present a conceptual framework and provide examples of studies that have taken first steps towards development of a quantitative framework that scales from within-host infections to population-level fitness of different pathogens. We hope to illustrate some general themes, summarize some of the recent advances and-maybe most importantly-discuss gaps in our ability to bridge these scales, and to stimulate future research on this important topic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.