ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Interactions between multiple helminths and the gut microbiota in wild rodents.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MICHELINdb: a web-based tool for mining of helminth-microbiota interaction datasets, and a meta-analysis of current research.Microbiome · 2020Pooled it
- Helminth Infection, Gut Microbiome Alterations, and Their Impact on Pulmonary Tuberculosis Susceptibility.Journal of tropical medicine · 2026Review
- Challenging the paradigm: the Asian fish tapeworm (Schyzocotyle acheilognathi, Yamaguti 1934) lacks an intrinsic symbiotic bacterial community.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Impacts of Tick Parasitism on the Rodent Gut Microbiome.Microorganisms · 2025Article
- 16S rDNA-based detection technology: use in lambs infected with Nematodirus oiratianus to analyze changes in intestinal flora.Parasite (Paris, France) · 2025Article
- Cichlid fishes are promising underutilized models to investigate helminth-host-microbiome interactions.Frontiers in immunology · 2025Review
- Comparison of naturalization mouse model setups uncover distinct effects on intestinal mucosa depending on microbial experience.Discovery immunology · 2025Article
- Helminths in alternative therapeutics of inflammatory bowel disease.Intestinal research · 2025Review
- Climate influences the gut eukaryome of wild rodents in the Great Rift Valley of Jordan.Parasites & vectors · 2024Article
- Metabarcoding study of potential pathogens and zoonotic risks associated with dog feces in Seoul, South Korea.PLoS neglected tropical diseases · 2024Article
- The strength of gut microbiota transfer along social networks and genealogical lineages in the house mouse.FEMS microbiology ecology · 2024Article
- Comparison of DNA extraction methods on different sample matrices within the same terrestrial ecosystem.Scientific reports · 2024Article
- Effects of past and present habitat on the gut microbiota of a wild rodent.Proceedings. Biological sciences · 2024Article
- Parasite-gut microbiota associations in wild wood mice (Frontiers in microbiology · 2024Article
- Human-influenced diets affect the gut microbiome of wild baboons.Scientific reports · 2023Article
- Species interactions, stability, and resilience of the gut microbiota - Helminth assemblage in horses.iScience · 2023Article
- The impact of the striped field mouse's range expansion on communities of native small mammals.Scientific reports · 2023Article
- Article
- Interactions between the helminth and intestinal microbiome in smallholder chicken farming systems.Frontiers in veterinary science · 2023Review
- Alterations of gut microbiota and short-chain fatty acids induced byFrontiers in microbiology · 2023Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut microbiota is vital to host health and, as such, it is important to elucidate the mechanisms altering its composition and diversity. Intestinal helminths are host immunomodulators and have evolved both temporally and spatially in close association with the gut microbiota, resulting in potential mechanistic interplay. Host-helminth and host-microbiota interactions are comparatively well-examined, unlike microbiota-helminth relationships, which typically focus on experimental infection with a single helminth species in laboratory animals. Here, in addition to a review of the literature on helminth-microbiota interactions, we examined empirically the association between microbiota diversity and composition and natural infection of multiple helminth species in wild mice (Apodemus flavicollis), using 16S rRNA gene catalogues (metataxonomics). In general, helminth presence is linked with high microbiota diversity, which may confer health benefits to the host. Within our wild rodent system variation in the composition and abundance of gut microbial taxa associated with helminths was specific to each helminth species and occurred both up- and downstream of a given helminth's niche (gut position). The most pronounced helminth-microbiota association was between the presence of tapeworms in the small intestine and increased S24-7 (Bacteroidetes) family in the stomach. Helminths clearly have the potential to alter gut homeostasis. Free-living rodents with a diverse helminth community offer a useful model system that enables both correlative (this study) and manipulative inference to elucidate helminth-microbiota interactions.
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