Evidence map›Paper›PMID 26150615›Full record

ArticleBMJ case reports2015

Wireless capsule endoscopy as a tool in diagnosing autoimmune enteropathy.

Eva-Marie Gram-Kampmann, Søren T Lillevang, Sönke Detlefsen, Stig Borbjerg Laursen

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Eva-Marie Gram-KampmannDepartment of Medical Gastroenterology and Hepatology, Odense University Hospital, Odense C, Denmark.
Søren T LillevangDepartment of Clinical Immunology, Odense University Hospital, Odense C, Denmark.
Sönke DetlefsenDepartment of Pathology, Odense University Hospital, Odense C, Denmark.
Stig Borbjerg LaursenDepartment of Medical Gastroenterology and Hepatology, Odense University Hospital, Odense C, Denmark.
Odense University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune enteropathy (AE) is an immune mediated illness of the intestinal mucosa. The cause is unknown, and the diagnosis is based on typical characteristics displayed. There is no gold standard for treatment. We present two adult cases of AE and demonstrate the challenges in establishing the diagnosis. The extensive diagnostic work up excluded other more common causes of protracted diarrhoea. Wireless capsule endoscopy (WCE) displayed universal small intestinal mucosal damage with shortened villi that led to the suspicion of AE in both patients. The diagnosis was confirmed with microscopy, showing shortened villi, villous blunting and hyperplasia of crypts in both patients. In one patient, deep crypt lymphocytosis with minimal intraepithelial lymphocytosis was found as well. Both patients were successfully treated with high-dose immunosuppressant therapy to induce and maintain remission. Use of WCE as a diagnostic tool was invaluable in establishing the diagnosis of AE.

Indexed as

Capsule EndoscopyAbdominal PainAdultAzathioprineDiagnosis, DifferentialDiarrheaFemaleHumansImmunosuppressive AgentsIntestinal MucosaIntestine, SmallMalePolyendocrinopathies, AutoimmunePrednisoneTreatment OutcomeWeight GainAzathioprineImmunosuppressive AgentsPrednisone

Identifiers

PMID26150615
PMCPMC4493217
OpenAlexW1854012118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.