ArticleEuropean journal of histochemistry : EJH2015
Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription.
Article in European journal of histochemistry : EJH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 51 citations in OpenAlex.
- Efficacy of ozonized water for the treatment of erosive oral lichen planus: a randomized controlled study.Medicina oral, patologia oral y cirugia bucal · 2020Trial
- Dose-Related Structural and Functional Modifications of Mitochondria Are Induced In Vitro by Low Ozone Concentrations.International journal of molecular sciences · 2026Article
- Ozone water enema activates SIRT1-Nrf2/HO-1 pathway to ameliorate gut dysbiosis in mice receiving COVID-19 patient-derived faecal microbiota.Journal of medical microbiology · 2025Article
- Insights into the use of oxygen-ozone therapy in ischemic cardiopathy and cardiovascular disease: a role for mitochondria?Medical gas research · 2024Article
- Low ozone concentrations do not exert cytoprotective effects on tamoxifen-treated breast cancer cellsEuropean journal of histochemistry : EJH · 2024Article
- Ozone Exposure Controls Oxidative Stress and the Inflammatory Process of Hepatocytes in Murine Models.Antioxidants (Basel, Switzerland) · 2024Review
- Ozone and procaine increase secretion of platelet-derived factors in platelet-rich plasma.European journal of histochemistry : EJH · 2023Article
- In Vitro Activity of Ozone/Oxygen Gaseous Mixture against a Caprine Herpesvirus Type 1 Strain Isolated from a Goat with Vaginitis.Animals : an open access journal from MDPI · 2023Article
- Mitochondrial Features of Mouse Myoblasts Are Finely Tuned by Low Doses of Ozone: The Evidence In Vitro.International journal of molecular sciences · 2023Article
- The Use of Medical Ozone in Chronic Intervertebral Disc Degeneration Can Be an Etiological and Conservative Treatment.International journal of molecular sciences · 2023Review
- Ozone at low concentration modulates microglial activity in vitro: A multimodal microscopy and biomolecular study.Microscopy research and technique · 2022Article
- Comments on the optimal use of medical ozone in clinics versus the Ozone High Dose Therapy (OHT) approach.Translational medicine communications · 2022Article
- Low Ozone Concentrations Differentially Affect the Structural and Functional Features of Non-Activated and Activated Fibroblasts In Vitro.International journal of molecular sciences · 2021Article
- Ozone as Modulator of Resorption and Inflammatory Response in Extruded Nucleus Pulposus Herniation. Revising Concepts.International journal of molecular sciences · 2021Review
- Ozone Activates the Nrf2 Pathway and Improves Preservation of Explanted Adipose Tissue In Vitro.Antioxidants (Basel, Switzerland) · 2020Article
- Ozone at low concentrations does not affect motility and proliferation of cancer cells in vitro.European journal of histochemistry : EJH · 2020Article
- Oxygen-Ozone (OTherapeutics and clinical risk management · 2020Review
- The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure.International journal of molecular sciences · 2019Review
- Ultrastructural histochemistry in biomedical research: Alive and kicking.European journal of histochemistry : EJH · 2018Article
- Low ozone concentrations promote adipogenesis in human adipose-derived adult stem cells.European journal of histochemistry : EJH · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ozone therapy is a modestly invasive procedure based on the regeneration capabilities of low ozone concentrations and used in medicine as an alternative/adjuvant treatment for different diseases. However, the cellular mechanisms accounting for the positive effects of mild ozonization are still largely unexplored. To this aim, in the present study the effects of low ozone concentrations (1 to 20 µg O3/mL O2) on structural and functional cell features have been investigated in vitro by using morphological, morphometrical, cytochemical and immunocytochemical techniques at bright field, fluorescence and transmission electron microscopy. Cells exposed to pure O2 or air served as controls. The results demonstrated that the effects of ozoneadministration are dependent on gas concentration, and the cytoskeletal organization, mitochondrial activity and nuclear transcription may be differently affected. This suggests that, to ensure effective and permanent metabolic cell activation, ozone treatments should take into account the cytological and cytokinetic features of the different tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.