ArticleScientific reports2015
Metabonomic analysis of potential biomarkers and drug targets involved in diabetic nephropathy mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Metabolomics approaches for the early detection and therapeutics: type 2 diabetes-induced diabetic kidney disease-a systematic review and meta-analysis.Metabolomics : Official journal of the Metabolomic Society · 2025Pooled it
- Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using (1)H-NMR-based metabolomics profiles.Scientific reports · 2016Trial
- Mendelian Randomization Study on Serum Metabolites and Diabetic Nephropathy Risk: Identifying Potential Biomarkers for Early Intervention.Current pharmaceutical design · 2026Article
- Multi-organ metabolome biological age implicates cardiometabolic conditions and mortality risk.Nature communications · 2025Article
- Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria.TouchREVIEWS in endocrinology · 2022Review
- A Contemporary Insight of Metabolomics Approach for Type 1 Diabetes: Potential for Novel Diagnostic Targets.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice.Drug design, development and therapy · 2022Article
- Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu.Scientific reports · 2021Article
- A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Serum and urine metabolomics reveal potential biomarkers of T2DM patients with nephropathy.Annals of translational medicine · 2020Article
- The Protective Effect of Basic Fibroblast Growth Factor on Diabetic Nephropathy Through Remodeling Metabolic Phenotype and Suppressing Oxidative Stress in Mice.Frontiers in pharmacology · 2020Article
- Metabolomics study of the anti-inflammatory effects of endogenous omega-3 polyunsaturated fatty acids.RSC advances · 2019Article
- Time-Course Changes in Urine Metabolic Profiles of Rats Following 90-Day Exposure to Propoxur.Scientific reports · 2019Article
- NMR metabolomics identifies over 60 biomarkers associated with Type II Diabetes impairment in db/db mice.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via anBioscience reports · 2019Article
- Article
- The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation.Acta pharmacologica Sinica · 2019Article
- Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.Scientific reports · 2018Article
- NMR-based urine metabolic profiling and immunohistochemistry analysis of nephron changes in a mouse model of hypoxia-induced acute kidney injury.American journal of physiology. Renal physiology · 2018Article
- Lacking ketohexokinase-A exacerbates renal injury in streptozotocin-induced diabetic mice.Metabolism: clinical and experimental · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetic nephropathy (DN) is one of the lethal manifestations of diabetic systemic microvascular disease. Elucidation of characteristic metabolic alterations during diabetic progression is critical to understand its pathogenesis and identify potential biomarkers and drug targets involved in the disease. In this study, (1)H nuclear magnetic resonance ((1)H NMR)-based metabonomics with correlative analysis was performed to study the characteristic metabolites, as well as the related pathways in urine and kidney samples of db/db diabetic mice, compared with age-matched wildtype mice. The time trajectory plot of db/db mice revealed alterations, in an age-dependent manner, in urinary metabolic profiles along with progression of renal damage and dysfunction. Age-dependent and correlated metabolite analysis identified that cis-aconitate and allantoin could serve as biomarkers for the diagnosis of DN. Further correlative analysis revealed that the enzymes dimethylarginine dimethylaminohydrolase (DDAH), guanosine triphosphate cyclohydrolase I (GTPCH I), and 3-hydroxy-3-methylglutaryl-CoA lyase (HMG-CoA lyase) were involved in dimethylamine metabolism, ketogenesis and GTP metabolism pathways, respectively, and could be potential therapeutic targets for DN. Our results highlight that metabonomic analysis can be used as a tool to identify potential biomarkers and novel therapeutic targets to gain a better understanding of the mechanisms underlying the initiation and progression of diseases.
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