ArticleActa ophthalmologica2016
Ageing effect on flicker-induced diameter changes in retinal microvessels of healthy individuals.
Article in Acta ophthalmologica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Aging affects retinal oxygen and blood flow metrics in mice.Experimental eye research · 2025Article
- Associations of retinal neurovascular dysfunction with inner retinal layer thickness in non-proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Endothelial dysfunction in retinal vessels of hemodialysis patients compared to healthy controls.Scientific reports · 2024Article
- Dynamic retinal vessel analysis: flickering a light into the brain.Frontiers in aging neuroscience · 2024Review
- Macro- and Microvascular Function in Middle-Aged Individuals with Low Cardiovascular Disease Risk.Journal of clinical medicine · 2022Article
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- Variation within the visually evoked neurovascular coupling response of the posterior cerebral artery is not influenced by age or sex.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
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- Oxysterols and Retinal Microvascular Dysfunction as Early Risk Markers for Cardiovascular Disease in Normal, Ageing Individuals.Antioxidants (Basel, Switzerland) · 2021Article
- Normative data and standard operating procedures for static and dynamic retinal vessel analysis as biomarker for cardiovascular risk.Scientific reports · 2021Article
- European Society of Cardiology/European Society of Hypertension versus the American College of Cardiology/American Heart Association guidelines on the cut-off values for early hypertension: a microvascular perspective.Scientific reports · 2021Article
- Quantification of Retinal Vessel Myogenic Constriction in Response to Blood Pressure Peaks: Implications for Flicker Light-Induced Dilatation.Frontiers in physiology · 2021Article
- Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.Cardiovascular research · 2021Review
- Retinal Vessel Responses to Flicker Stimulation Are Impaired in CaFrontiers in neurology · 2021Article
- Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
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- Retinal Endothelial Function, Physical Fitness and Cardiovascular Risk: A Diagnostic Challenge.Frontiers in physiology · 2019Article
- Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.Neurobiology of aging · 2018Article
- Cardiovascular risk factors as determinants of retinal and skin microvascular function: The Maastricht Study.PloS one · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare flicker-induced retinal vessel diameter changes in varying age groups with low cardiovascular risk.
methodsRetinal vascular reactivity to flicker light was assessed by means of dynamic retinal vessel analysis in 57 participants aged 19-30 years, 75 participants aged 31-50 years and 62 participants aged 51-70 years participants. Other assessments included carotid intima-media thickness (c-IMT), augmentation index (AIx), blood pressure profiles, blood lipid metabolism markers and Framingham risk scores (FRS).
resultsRetinal arterial dilation amplitude (DA) and postflicker percentage constriction (MC%) were significantly decreased in the oldest group compared to the middle-aged (p = 0.028; p = 0.021) and youngest group (p = 0.003; p = 0.026). The arterial constriction slope (SlopeAC ) was also decreased in the oldest group compared to the youngest group (p = 0.027). On the venous side, MC% was decreased in the middle-aged and oldest groups in comparison with the youngest group (p = 0.015; p = 0.010, respectively). Additionally, men exhibited increased arterial DA (p = 0.007), and percentage dilation (MD%, p < 0.001) in comparison with women, but only in the youngest age group. Both AIx and c-IMT scores increased with age (both p < 0.001); however, no correlations were found between the observed differences in the measured retinal vascular function and systemic parameters.
conclusionIn individuals with low cardiovascular risk, there are age-related differences in flicker-induced retinal vessel diameter changes throughout the entire functional response curve for arteries and veins. Gender differences mainly affect the arterial dilatory phase and are only present in young individuals.
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